ML346

Base Information

Chemical Name:ML346
CAS No.:100872-83-1
Molecular Formula:C14H12N2O4
Molecular Weight:272.26
Hs Code.:
Mol file:100872-83-1.mol

Synonyms:ML346

Suppliers and Price of ML346

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
ML-346 >98%
1 g
$ 1700.00

DC Chemicals
ML-346 >98%
250 mg
$ 900.00

DC Chemicals
ML-346 >98%
100 mg
$ 550.00

CSNpharm
ML346
100mg
$ 512.00

CSNpharm
ML346
5mg
$ 84.00

CSNpharm
ML346
25mg
$ 250.00

Crysdot
ML346 98+%
5mg
$ 243.00

Crysdot
ML346 98+%
100mg
$ 1459.00

Crysdot
ML346 98+%
10mg
$ 347.00

ChemScene
ML346 ≥98.0%
50mg
$ 350.00

Total 12 raw suppliers

Chemical Property of ML346

Chemical Property:

Melting Point:266-268 °C(Solv: ethyl acetate (141-78-6))
PKA:7.42±0.20(Predicted)
PSA：84.50000
Density:1.374±0.06 g/cm3(Predicted)
LogP:1.65840

Purity/Quality:

99%, ^*data from raw suppliers

ML-346 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27. It induces the expression of the oxidative stress response genes HO1, GCLM, and BiP in mouse embryonic fibroblasts (MEFs) and pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis. It promotes folding of metastable proteins in models of conformational disease, including cellular models of Huntingtin aggregation and cystic fibrosis. It reduces aggregate formation in PC12 cells expressing human Huntingtin exon 1 containing a 74 glutamine expansion when used at a concentration of 10 μM. It also corrects trafficking of cystic fibrosis transmembrane conductance regulator proteins bearing the F508 deletion (ΔF508-CFTR) mutation carried by the majority of cystic fibrosis patients, leading to increased cell surface expression.

Technology Process of ML346

There total 3 articles about ML346 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 100872-83-1
5-(4-methoxy-trans-cinnamylidene)-barbituric acid

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃ / anschliessenden Behandeln mit wss.Natriumacetat

With trichlorophosphate;
DOI:10.1002/hlca.19550380144