BENZENEACETIC ACID, 2-CHLORO-A-[[2-(2-THIENYL)ETHYL]AMINO]-, METHYL ESTER, (+)-, (1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE

Base Information

• Chemical Name: BENZENEACETIC ACID, 2-CHLORO-A-[[2-(2-THIENYL)ETHYL]AMINO]-, METHYL ESTER, (+)-, (1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE
• CAS No.: 141109-21-9
• Molecular Formula: C₁₀H₁₆O₄S*C₁₅H₁₆ClNO₂S
• Molecular Weight: 542.117
• Mol file: 141109-21-9.mol

Synonyms:BENZENEACETIC ACID, 2-CHLORO-A-[[2-(2-THIENYL)ETHYL]AMINO]-, METHYL ESTER, (+)-, (1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE

Chemical Property of BENZENEACETIC ACID, 2-CHLORO-A-[[2-(2-THIENYL)ETHYL]AMINO]-, METHYL ESTER, (+)-, (1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE

Chemical Property:

• PSA: 146.39000
• LogP: 6.18920

Purity/Quality:

97% ^*data from raw suppliers

(1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE-2-CHLORO-ALPHA-[[2-(2-THIENYL)ETHYL]AMINO]-(+)BENZENEACETIC ACID METHYL ESTER, 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZENEACETIC ACID, 2-CHLORO-A-[[2-(2-THIENYL)ETHYL]AMINO]-, METHYL ESTER, (+)-, (1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE

There total 2 articles about BENZENEACETIC ACID, 2-CHLORO-A-[[2-(2-THIENYL)ETHYL]AMINO]-, METHYL ESTER, (+)-, (1S)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-METHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(2-thiophen-2-yl ethylamino)(2-chlorophenyl)acetic acid methyl ester (141109-26-4) + L-10-camphorsulfonic acid (61380-66-3) → (+)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester (-)-camphorsulfonic acid salt (141109-21-9)

Guidance literature:

In acetone; at 20 ℃; for 48h;

Reference yield:

methyl [2-(thien-2-yl)ethylamino](2-chlorophenyl)-acetate hydrochloride (141109-18-4,141109-19-5) + (1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) → C15H16ClNO2S*C10H16O4S (141109-21-9)

Guidance literature:

methyl [2-(thien-2-yl)ethylamino](2-chlorophenyl)-acetate hydrochloride; With sodium carbonate; In dichloromethane; water;

(1S)-10-camphorsulfonic acid; In acetone; at 20 ℃; for 24h;

upstream raw materials:

2-(2-thiophen-2-yl ethylamino)(2-chlorophenyl)acetic acid methyl ester

L-10-camphorsulfonic acid

methyl [2-(thien-2-yl)ethylamino](2-chlorophenyl)-acetate hydrochloride

(1S)-10-camphorsulfonic acid

Refernces

• 1、 -. "Process for racemization". Page column 6-7. . Retrieved 2010/02/06.