141109-26-4Relevant articles and documents
Synthetic method of racemic clopidogrel
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Paragraph 0031-0032; 0034; 0038-0039; 0042-0043; 0045, (2020/09/12)
The invention relates to a synthesis method of racemic clopidogrel, which comprises the following steps: 1) uniformly mixing methyl benzoylformate, N-chlorosuccinimide, palladium acetate, a ligand andtrifluoroacetic acid, and carrying out ortho-chlorinati
Concise Synthesis of (±)-Clopidogrel via Carboxylation of Benzylamine with CO2
Venkataramasubramanian,Sudalai, Arumugam
, p. 2099 - 2105 (2015/09/01)
A concise and efficient synthesis of (±)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.
Process for the preparation of a pharmacologically active substance
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, (2008/06/13)
The present invention relates to a process for the preparation of the racemic or optically active compounds of general formula (VI): wherein the meaning of X is a halogen atom, or their salts, characterized in that, a racemic or optically active new compound of general formula (VII): wherein the meaning of X is a halogen atom, is transformed into the racemic or optically active compound of general formula (VIII):
