2H-Pyrido[3,4-b]indole-2-carboxylic acid, 6-bromo-1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2H-Pyrido[3,4-b]indole-2-carboxylic acid, 6-bromo-1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester
• CAS No.: 1173155-59-3
• Molecular Formula: C₁₆H₁₉BrN₂O₂
• Molecular Weight: 351.243
• Mol file: 1173155-59-3.mol

Synonyms:2H-Pyrido[3,4-b]indole-2-carboxylic acid, 6-bromo-1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester;tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Chemical Property of 2H-Pyrido[3,4-b]indole-2-carboxylic acid, 6-bromo-1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 45.33000
• LogP: 4.16150

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl6-Bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of 2H-Pyrido[3,4-b]indole-2-carboxylic acid, 6-bromo-1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester

There total 1 articles about 2H-Pyrido[3,4-b]indole-2-carboxylic acid, 6-bromo-1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-bromo-1,2,3,4-tetrahydro-β-carboline (23046-69-7) → tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1173155-59-3)

Guidance literature:

In tetrahydrofuran; dichloromethane; for 2.5h;

Reference yield:

tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1173155-59-3) + 1-(3-bromopropoxy)-4-chlorobenzene (27983-04-6) → C25H28BrClN2O3

Guidance literature:

tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.583333h; Cooling with ice;

1-(3-bromopropoxy)-4-chlorobenzene; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.8b01598

Reference yield:

tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1173155-59-3) + methyl 2-(4-(3-bromopropoxy)phenyl)acetate (203071-48-1) → C28H33BrN2O5

Guidance literature:

tert-butyl 6-bromo-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.583333h;

methyl 2-(4-(3-bromopropoxy)phenyl)acetate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.0c01763

upstream raw materials:

di-tert-butyl dicarbonate

6-bromo-1,2,3,4-tetrahydro-β-carboline

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