.beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)-

Base Information

• Chemical Name: .beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)-
• CAS No.: 165874-28-2
• Molecular Formula: C56H50N2O13
• Molecular Weight: 959

Synonyms:.beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)-

Chemical Property of .beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)-

Chemical Property:

• Melting Point: 129 - 132 °C
• PKA: 11.81±0.70(Predicted)
• PSA: 168.83000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 6.52090

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of .beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)-

There total 15 articles about .beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → 3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-benzylidene-2-deoxy-2-phthalimido-β-D-allopyranosyl)-2-deoxy-2-phthalimido-β-D-allopyranose (165874-28-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 94 percent / barium oxide, barium hydroxide / dimethylformamide / 16 h / 20 °C

2: 1.) KOH / 1.) CH₃OH, H₂O, 125 deg C, 5 d, 2.) CHCl₃, 20 deg C, 20 min

3: 89 percent / 2)2>PF₆ / tetrahydrofuran / 1.5 h

4: 91 percent / HgCl₂ / acetone; H₂O / 3 h / 20 °C

5: 4A MS, DBU / CH₂Cl₂ / 0.25 h / 0 °C

6: 4A MS, trimethylsilyl triflate / CH₂Cl₂ / 0.25 h / -30 °C

7: 1.) DBU, tris(triphenylphosphine)rhodium(I) chloride, 2.) HgCl₂ / 1.) ethanol, benzene, water, reflux, 24 h, 2.) acetone, H₂O, 20 deg C, 3 h

With barium dihydroxide; potassium hydroxide; Wilkinson's catalyst; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; mercury dichloride; barium(II) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

phthalic anhydride (85-44-9) → 3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-benzylidene-2-deoxy-2-phthalimido-β-D-allopyranosyl)-2-deoxy-2-phthalimido-β-D-allopyranose (165874-28-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) KOH / 1.) CH₃OH, H₂O, 125 deg C, 5 d, 2.) CHCl₃, 20 deg C, 20 min

2: 89 percent / 2)2>PF₆ / tetrahydrofuran / 1.5 h

3: 91 percent / HgCl₂ / acetone; H₂O / 3 h / 20 °C

4: 4A MS, DBU / CH₂Cl₂ / 0.25 h / 0 °C

5: 4A MS, trimethylsilyl triflate / CH₂Cl₂ / 0.25 h / -30 °C

6: 1.) DBU, tris(triphenylphosphine)rhodium(I) chloride, 2.) HgCl₂ / 1.) ethanol, benzene, water, reflux, 24 h, 2.) acetone, H₂O, 20 deg C, 3 h

With potassium hydroxide; Wilkinson's catalyst; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; mercury dichloride; In tetrahydrofuran; dichloromethane; water; acetone;

Reference yield:

allyl 2-deoxy-2-acetamido-4,6-O-benzylidene-β-D-glucopyranoside (65947-37-7) → 3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-benzylidene-2-deoxy-2-phthalimido-β-D-allopyranosyl)-2-deoxy-2-phthalimido-β-D-allopyranose (165874-28-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 89 percent / pyridine / 16 h / 4 °C

2: 91 percent / sodium acetate / 2-methoxy-ethanol; H₂O / 9 h / 125 °C

3: 94 percent / barium oxide, barium hydroxide / dimethylformamide / 16 h / 20 °C

4: 1.) KOH / 1.) CH₃OH, H₂O, 125 deg C, 5 d, 2.) CHCl₃, 20 deg C, 20 min

5: 89 percent / 2)2>PF₆ / tetrahydrofuran / 1.5 h

6: 91 percent / HgCl₂ / acetone; H₂O / 3 h / 20 °C

7: 4A MS, DBU / CH₂Cl₂ / 0.25 h / 0 °C

8: 4A MS, trimethylsilyl triflate / CH₂Cl₂ / 0.25 h / -30 °C

9: 1.) DBU, tris(triphenylphosphine)rhodium(I) chloride, 2.) HgCl₂ / 1.) ethanol, benzene, water, reflux, 24 h, 2.) acetone, H₂O, 20 deg C, 3 h

With barium dihydroxide; potassium hydroxide; Wilkinson's catalyst; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; trimethylsilyl trifluoromethanesulfonate; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; mercury dichloride; barium(II) oxide; In tetrahydrofuran; pyridine; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

allyl 3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-benzylidene-2-deoxy-2-phthalimido-β-D-allopyranosyl)-2-deoxy-2-phthalimido-β-D-allopyranoside

phthalic anhydride

allyl 2-deoxy-2-acetamido-4,6-O-benzylidene-β-D-glucopyranoside

benzyl bromide

Downstream raw materials:

C₅₈H₅₀Cl₃N₃O₁₃

(1S,5S)-3-dimethylamino-8-exo-hydroxymethyl-7-endo-hydroxy-2-oxa-4-azabicyclo<3.3.0>oct-3-en-6-endo-yl 2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-allopyranosyl)-2-deoxy-β-D-allopyranoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 165874-28-2 .beta.-D-Allopyranose, 2-deoxy-4-O-2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-O-(phenylmethyl)-4,6-O-(phenylmethylene)-.beta.-D-allopyranosyl-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,6-bis-O-(phenylmethyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send