SHP099 (hydrochloride)

Base Information

• Chemical Name: SHP099 (hydrochloride)
• CAS No.: 1801747-11-4
• Molecular Formula: C16H20Cl3N5
• Molecular Weight: 388.72
• Mol file: 1801747-11-4.mol

Synonyms:SHP099 (hydrochloride);6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-Pyrazinamine hydrochloride;6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride;SHP099 HCl

Chemical Property of SHP099 (hydrochloride)

Chemical Property:

• PSA: 81.06000
• LogP: 5.49870

Purity/Quality:

99%, ^*data from raw suppliers

SHP099 Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: SHP099 Hydrochloride is a useful reagent for the preparation of substituted piperidinylpyrazinamines and analogs for inhibiting the activity of SHP2 useful in treating diseases.

Technology Process of SHP099 (hydrochloride)

There total 1 articles about SHP099 (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butoxycarbonylamino-4-methylpiperidine (163271-08-7) + 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine (212779-33-4) → 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride (1801747-11-4)

Guidance literature:

With 4-methyl-morpholine; In 1-methyl-pyrrolidin-2-one; at 250 ℃; for 2h; Microwave irradiation;

Reference yield: 50.0%

SHP-099 (1801747-11-4) + propargyl bromide (106-96-7) → 3-(2,3-dichlorophenyl)-6-(4-methyl-4-(prop-2-yn-1-ylamino)piperidin-1-yl)pyrazin-2-amine

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 85 ℃; for 6h;

DOI:10.1016/j.bioorg.2021.104788

upstream raw materials:

4-tert-butoxycarbonylamino-4-methylpiperidine

6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine

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