(S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate

Base Information

Chemical Name:(S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate
CAS No.:868694-44-4
Molecular Formula:C14H19IN2O3
Molecular Weight:390.221
Hs Code.:2924299090

Synonyms:(S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate

Suppliers and Price of (S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl[(S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate
1g
$ 1320.00

Crysdot
(S)-tert-Butyl(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate 95+%
1g
$ 550.00

Alichem
(S)-Tert-Butyl(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate
1g
$ 579.15

Total 8 raw suppliers

Chemical Property of (S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate

Chemical Property:

PSA：81.42000
LogP:3.30350

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl[(S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses tert-Butyl [(S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate can be used to prepare cathepsin C inhibitors.

Technology Process of (S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate

There total 4 articles about (S)-tert-butyl (1-aMino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate; In 1,4-dioxane; for 16h;
DOI:10.1021/jm0504555

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 48 h / 20 °C

2: HATU; benzotriazol-1-ol; ammonium chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium carbonate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2021.128202

Reference yield:

: 1991-81-7,14173-41-2,24250-85-9,62561-75-5
4-iodo-L-phenylalanine

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 48 h / 20 °C

2: HATU; benzotriazol-1-ol; ammonium chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium carbonate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2021.128202