(S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

Base Information

Chemical Name:(S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate
CAS No.:1352151-70-2
Molecular Formula:C₂₈H₃₄N₄O₄
Molecular Weight:490.602
Hs Code.:

Synonyms:(S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

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Chemical Property of (S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

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Technology Process of (S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

There total 4 articles about (S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1254318-97-2
(S)-2-amino-3-(4'-cyanobiphenyl-4-yl)propanamide

: 115951-16-1
1-tert-butoxycarbonylaminocyclohexanecarboxylic acid

: 1352151-70-2
(S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm401705g

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1352151-70-2
(S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 0 - 28 °C

2.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 17 - 28 °C

With N-ethylmorpholine;; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

: 1352151-70-2
(S)-tert-butyl-1-(1-amino-3-(4'-cyanobiphenyl-4yl)-1-oxopropan-2-yl carbamoyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane

3: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 17 - 28 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;