4-Bromo-2-iodo-6-nitroaniline

Base Information

• Chemical Name: 4-Bromo-2-iodo-6-nitroaniline
• CAS No.: 180624-08-2
• Molecular Formula: C6H4BrIN2O2
• Molecular Weight: 342.918
• Hs Code.: 2921420090
• DSSTox Substance ID: DTXSID60443570
• Wikidata: Q82261458
• Mol file: 180624-08-2.mol

Synonyms:4-bromo-2-iodo-6-nitroaniline;180624-08-2;4-Bromo-2-iodo-6-nitrobenzenamine;MFCD11110560;C6H4BrIN2O2;SCHEMBL222175;DTXSID60443570;CUVSESOKQSEEHQ-UHFFFAOYSA-N;AMY32310;(4-bromo-2-iodo-6-nitrophenyl)amine;AKOS016000201;SB83279;Benzenamine, 4-bromo-2-iodo-6-nitro-;DS-15717;SY023691;CS-0097729;A881100

Chemical Property of 4-Bromo-2-iodo-6-nitroaniline

Chemical Property:

• PSA: 71.84000
• LogP: 3.64850
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 341.85009
• Heavy Atom Count: 12
• Complexity: 187

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-iodo-6-nitro-phenylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])N)I)Br
• Uses: 4-Bromo-2-iodo-6-nitroaniline is a useful research chemical compound.

Technology Process of 4-Bromo-2-iodo-6-nitroaniline

There total 4 articles about 4-Bromo-2-iodo-6-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Bromo-2-nitroaniline (875-51-4) → 4-bromo-2-nitro-6-iodoaniline (180624-08-2)

Guidance literature:

With trifluorormethanesulfonic acid; [bis(pyridine)iodine]⁺ tetrafluoroborate; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jo952119+

Reference yield: 89.0%

→ 4-bromo-2-nitro-6-iodoaniline (180624-08-2)

Guidance literature:

With iodine; silver sulfate; In methanol; at 20 ℃; for 12h;

Reference yield:

2-nitro-aniline (88-74-4) → 4-bromo-2-nitro-6-iodoaniline (180624-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid; sodium acetate / beim Bromieren

2: p-toluenesulfonic acid dichloroamide; glacial acetic acid; sodium iodide

With N,N-dichloro-p-toluenesulfonamide; sodium acetate; acetic acid; sodium iodide;

upstream raw materials:

4-Bromo-2-nitroaniline

N,N-dichloro-p-toluenesulfonamide

acetic acid

2-nitro-aniline

Refernces

• 1、 Ramadoss, Velayudham,Alonso-Castro, Angel Josabad,Campos-Xolalpa, Nimsi,Solorio-Alvarado, César R.. "Protecting-Group-Free Total Synthesis and Biological Evaluation of 3-Methylkealiiquinone and Structural Analogues". . p. 10627 - 10635. Retrieved 2018.
• 2、 -. "HETEROCYCLIC GLP-1 AGONISTS". Page/Page column 181-182. . Retrieved 2021/08/14.