DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95

Base Information

• Chemical Name: DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95
• CAS No.: 83213-60-9
• Molecular Formula: C₈H₁₅NO₃S
• Molecular Weight: 205.278
• Mol file: 83213-60-9.mol

Synonyms:DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95;dl-S-B-hydroxybutyryl-N-acetyl*cysteamine approx;DL-S-B-HYDROXYBUTYRYL-N-ACETYL*CYSTEAMIN E APPROX 98;DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95%

Chemical Property of DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95

Chemical Property:

• PSA: 91.70000
• LogP: 0.54410

Purity/Quality:

97% ^*data from raw suppliers

DL-S-BETA-HYDROXYBUTYRYL-N-ACETYLCYSTEAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95

There total 7 articles about DL-S-B-HYDROXYBUTYRYL-N-ACETYL CYSTEAMIN E APPROX 95 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

C14H29NO3SSi → (R)-3-Hydroxy-thiobutyric acid S-(2-acetylamino-ethyl) ester (67024-17-3,83213-60-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 120h;

DOI:10.1039/c6cc10172k

Reference yield: 12.0%

2-(acetylamino)ethanethiol (1190-73-4) + sodium (R)-3-hydroxybutyrate (13613-65-5) → (R)-3-Hydroxy-thiobutyric acid S-(2-acetylamino-ethyl) ester (67024-17-3,83213-60-9)

Guidance literature:

sodium (R)-3-hydroxybutyrate; With trifluorormethanesulfonic acid; In dichloromethane; at 0 ℃; for 1h;

2-(acetylamino)ethanethiol; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 22 ℃; for 16h;

DOI:10.1021/acs.joc.9b02688

Reference yield:

3-oxobutanoyl-N-acetylcysteamine thioester (23255-41-6) → S-(2-acetamidoethyl) (RS)3-hydroxybutanethioate (166900-21-6,83213-60-9)

Guidance literature:

With ketoreductase YsfH; NADPH; In glycerol; at 30 ℃; for 3h; Enzymatic reaction;

DOI:10.1002/anie.202007777

upstream raw materials:

(R)-3-hydroxybutyric acid

2-(acetylamino)ethanethiol

3-oxobutanoyl-N-acetylcysteamine thioester

S-Crotonyl-N-acetylcysteamin

Refernces

• 1、 Tang, Man-Cheng,Fischer, Curt R.,Chari, Jason V.,Tan, Dan,Suresh, Sundari,Chu, Angela,Miranda, Molly,Smith, Justin,Zhang, Zhuan,Garg, Neil K.,Onge, Robert P. St.,Tang, Yi. "Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi". . p. 8198 - 8206. Retrieved 2019/06/07.
• 2、 Liu, Yating,Su, Li,Fang, Qing,Tabudravu, Jioji,Yang, Xiaohui,Rickaby, Kirstie,Trembleau, Laurent,Kyeremeh, Kwaku,Deng, Zixin,Deng, Hai,Yu, Yi. "Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A". supporting information. p. 16323 - 16328. Retrieved 2019/12/02.