4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE

Base Information

• Chemical Name: 4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE
• CAS No.: 884504-63-6
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.084
• Hs Code.: 2926909090
• Mol file: 884504-63-6.mol

Synonyms:4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE

Chemical Property of 4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE

Chemical Property:

• Vapor Pressure: 2.64E-06mmHg at 25°C
• Boiling Point: 390.5°C at 760 mmHg
• Flash Point: 190°C
• PSA: 40.86000
• Density: 1.455g/cm³
• LogP: 2.93558

Purity/Quality:

97% ^*data from raw suppliers

4-(3-Bromophenyl)-4-oxobutyronitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE

There total 4 articles about 4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

m-bromobenzoic aldehyde (3132-99-8) + acrylonitrile (107-13-1,25014-41-9) → 4-(3-bromophenyl)-4-oxobutanenitrile (884504-63-6)

Guidance literature:

With sodium cyanide; In N,N-dimethyl-formamide; at 35 ℃; for 3h;

Reference yield: 55.0%

C10H9BrO2 + acetonitrile (75-05-8,26809-02-9) → 4-(3-bromophenyl)-4-oxobutanenitrile (884504-63-6)

Guidance literature:

With iron(III) chloride; silver carbonate; at 120 ℃; for 24h; Schlenk technique;

DOI:10.1016/j.tetlet.2019.04.042

Reference yield:

1-(3-Bromophenyl)ethanone (2142-63-4) → 4-(3-bromophenyl)-4-oxobutanenitrile (884504-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 24 h / 120 °C

2: silver carbonate; iron(III) chloride / 24 h / 120 °C / Schlenk technique

With iron(III) chloride; toluene-4-sulfonic acid; silver carbonate;

DOI:10.1016/j.tetlet.2019.04.042

upstream raw materials:

m-bromobenzoic aldehyde

acrylonitrile

acetonitrile

1-(3-Bromophenyl)ethanone

Downstream raw materials:

3-(3-(3-(5-aminopyridin-2-yl)phenyl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

N-(6-(3-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenyl)pyridin-3-yl)benzenesulfonamide

1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

2-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-[1,1'-biphenyl]-3-yl)acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 884504-63-6 4-(3-BROMOPHENYL)-4-OXOBUTYRONITRILE

Send

Send

Metric Ton KG G Pound L ML

Send

Send