2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine
• CAS No.: 378766-08-6
• Molecular Formula: C14H11FN2
• Molecular Weight: 226.25
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60352395
• Nikkaji Number: J3.219.941K
• Wikidata: Q82129519
• Mol file: 378766-08-6.mol

Synonyms:2-(4-fluorophenyl)-7-methylimidazo[1,2-a]pyridine;378766-08-6;Enamine_004771;Cambridge id 5691502;Oprea1_516657;SCHEMBL4727102;DTXSID60352395;HMS1407I19;BBL020192;CCG-18159;MFCD01456293;STK711895;AKOS000527515;BS-25092;CS-0207506;AB00093757-01;EN300-1221314;Z55862558;F1967-6037;2-(4-Fluoro-phenyl)-7-methyl-1H-imidazo[1,2-a]pyridine

Chemical Property of 2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine

Chemical Property:

• PSA: 17.30000
• LogP: 3.44880
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 226.09062652
• Heavy Atom Count: 17
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC(=CN2C=C1)C3=CC=C(C=C3)F
• Uses: 2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine

Technology Process of 2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine

There total 2 articles about 2-(4-Fluorophenyl)-7-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-(4-fluorophenyl)-7-methylimidazo[1,2-a]pyridine (378766-08-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 80 °C

2: dichloromethane / 24 h / 20 °C

3: copper dichloride / 1,2-dichloro-ethane / 90 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; copper dichloride; In ethanol; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.tetlet.2020.152147

Reference yield:

1-(4-fluorophenyl)ethanone oxime (329-79-3) → 2-(4-fluorophenyl)-7-methylimidazo[1,2-a]pyridine (378766-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C

2: copper dichloride / 1,2-dichloro-ethane / 90 °C / Inert atmosphere

With copper dichloride; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.tetlet.2020.152147

Reference yield: 99.0%

5-bromopyrimidine (4595-59-9) + 2-(4-fluorophenyl)-7-methylimidazo[1,2-a]pyridine (378766-08-6) → 2-(4-fluorophenyl)-7-methyl-3-(pyrimidin-5-yl)imidazo[1,2-a]pyridine

Guidance literature:

With [Pd(IPr*IMe)^An(3-Cl-pyridinyl)Cl₂]; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 130 ℃; for 12h; regioselective reaction;

DOI:10.1021/acs.organomet.0c00494

upstream raw materials:

1-(4-fluorophenyl)ethanone oxime

1-(4-fluorophenyl)ethanone