329-79-3

Basic information

• Product Name: 4-FLUOROACETOPHENONE OXIME
• Synonyms: 4’-fluoro-acetophenonoxime;4'-FLUOROACETOPHENONE OXIME;4-FLUOROACETOPHENONE OXIME;4-Fluoroacetophenone oxime,98%;1-(4-fluorophenyl)ethanone oxime
• CAS NO: 329-79-3
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.15
• Mol File: 329-79-3.mol
• Article Data: 65

Chemical Properties

• Melting Point: 72-74 °C
• Boiling Point: 239.8°Cat760mmHg
• Flash Point: 98.8°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0.0214mmHg at 25°C
• Refractive Index: 1.503
• PKA: 11.27±0.70(Predicted)
• CAS DataBase Reference: 4-FLUOROACETOPHENONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROACETOPHENONE OXIME(329-79-3)
• EPA Substance Registry System: 4-FLUOROACETOPHENONE OXIME(329-79-3)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 329-79-3(Hazardous Substances Data)

Usage

Chemical Properties

White to slightly yellow needles

InChI:InChI=1/C8H8FNO/c1-6(10-11)7-2-4-8(9)5-3-7/h2-5,11H,1H3/b10-6-

Upstream product

• 107093-07-2 1-(4-Fluoro-phenyl)-1-hydroxyamino-ethanol 
• 99-91-2 para-chloroacetophenone 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 546-88-3 acetylhydroxamic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 79-24-3 Nitroethane 
• 462-06-6 fluorobenzene 

Downstream Products

• 110319-94-3 2-(4-fluorophenyl)-1H-pyrrole 
• 351-83-7 4'-fluoroacetanilide 
• 1379999-33-3 dimethyl 5-(4-fluorophenyl)-1H-pyrrole-2,3-dicarboxylate 
• 1523451-30-0 6-fluoro-1-methyl-3,4-diphenylisoquinoline 2-oxide 
• 177750-13-9 N-(1-(4-fluorophenyl)vinyl)acetamide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 79039-69-3 6-chloro-2-(4-fluorophenyl)-4-phenylquinoline 
• 119830-49-8 2-(4-fluorophenyl)-5-methyl-1H-pyrrole 
• 748771-34-8 3-(4-Fluorophenyl)-5-(4-hydroxyphenyl)isoxazole 
• 31709-51-0 3-(4-fluorophenyl)isoxazol-5 (4H)-one 
• 403-40-7 1-(4-fluorophenyl)ethylamine 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.

Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na

A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois’ reagent as the CF3source. A series of β-CF3enamides were obtained in moderate to good yields with highE-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and theEisomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.