2-ethyl-2,3-dihydro-1H-Indene-2-carboxaldehyde

Base Information

• Chemical Name: 2-ethyl-2,3-dihydro-1H-Indene-2-carboxaldehyde
• CAS No.: 1262415-81-5
• Molecular Formula: C12H14O
• Molecular Weight: 174.23896
• Mol file: 1262415-81-5.mol

Synonyms:2-ethyl-2,3-dihydro-1H-Indene-2-carboxaldehyde

Chemical Property of 2-ethyl-2,3-dihydro-1H-Indene-2-carboxaldehyde

Chemical Property:

• Boiling Point: 267.1±29.0 °C(Predicted)
• Density: 1.081±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-2,3-dihydro-1H-Indene-2-carboxaldehyde

There total 2 articles about 2-ethyl-2,3-dihydro-1H-Indene-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

2-(2-bromobenzyl)-2-methylbutanal + 2-methoxyethylamine (109-85-3) → 2-ethyl-2,3-dihydro-1H-indene-2-carbaldehyde (1262415-81-5)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; palladium diacetate; silver trifluoroacetate; acetic acid; at 130 ℃; for 18h; Microwave irradiation; Inert atmosphere; Sealed tube;

DOI:10.1039/c9cc03644j

Reference yield:

2-Methylbutyraldehyde (96-17-3,57456-98-1) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 2-ethyl-2,3-dihydro-1H-indene-2-carbaldehyde (1262415-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetra-(n-butyl)ammonium iodide / benzene / 20 h / 60 °C / Inert atmosphere

2: palladium diacetate; silver trifluoroacetate; 1,1,1,3',3',3'-hexafluoro-propanol; acetic acid / 18 h / 130 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With 1,1,1,3',3',3'-hexafluoro-propanol; palladium diacetate; silver trifluoroacetate; tetra-(n-butyl)ammonium iodide; acetic acid; sodium hydroxide; In benzene;

DOI:10.1039/c9cc03644j

upstream raw materials:

2-methoxyethylamine

2-Methylbutyraldehyde

1-Bromo-2-bromomethyl-benzene

Refernces