2-METHOXYETHYLAMINE

Base Information

• Chemical Name: 2-METHOXYETHYLAMINE
• CAS No.: 109-85-3
• Molecular Formula: C3H9NO
• Molecular Weight: 75.1106
• Hs Code.: 29221990
• European Community (EC) Number: 203-712-1
• UNII: 743U9W3NIL
• DSSTox Substance ID: DTXSID1021908
• Nikkaji Number: J46.395G
• Wikidata: Q27266233
• ChEMBL ID: CHEMBL4101550
• Mol file: 109-85-3.mol

Synonyms:Ethylamine,2-methoxy- (6CI,7CI,8CI);1-Amino-2-methoxyethane;1-Methoxy-2-aminoethane;2-(Methyloxy)ethanamine;2-Aminoethyl methyl ether;2-Methoxy-1-aminoethane;2-Methoxy-1-ethanamine;2-Methoxyethanamine;2-Methoxyethylamine;N-(2-Methoxyethyl)amine;b-Methoxyethylamine;

Chemical Property of 2-METHOXYETHYLAMINE

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 46.3mmHg at 25°C
• Melting Point: -82 °C
• Refractive Index: n20/D 1.406(lit.)
• Boiling Point: 94.999 °C at 760 mmHg
• PKA: 9.89(at 10℃)
• Flash Point: 9.444 °C
• PSA: 35.25000
• Density: 0.853 g/cm³
• LogP: 0.29180
• Storage Temp.: Flammables area
• Water Solubility.: Completely miscible in water
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 75.068413911
• Heavy Atom Count: 5
• Complexity: 16.4

Purity/Quality:

99.0% ^*data from raw suppliers

2-Methoxyethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: COCCN
• Uses: 2-Methoxyethylamine is used as a reagent in the preparation of lipid-like materials for delivery of RNAi therapeutics.

Technology Process of 2-METHOXYETHYLAMINE

There total 71 articles about 2-METHOXYETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

N,N'-Di(2-methoxyethyl)thioharnstoff (1119-13-7) → 2-methoxyethylamine (109-85-3)

Guidance literature:

With dipotassium peroxodisulfate; In water; acetonitrile; at 80 ℃; for 6h; Temperature; Reagent/catalyst; Solvent;

Reference yield: 77.0%

2-(2-Methoxy-ethoxy)-isoindole-1,3-dione (54149-18-7) → 2-methoxyethylamine (109-85-3)

Guidance literature:

With methylhydrazine; In dichloromethane; at -10 ℃; for 2h;

Reference yield: 53.6%

(2-methoxyethyl)amine hydrochloride (18600-40-3) → 2-methoxyethylamine (109-85-3)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 - 25 ℃; for 1h;

DOI:10.1007/s11172-009-0256-3

upstream raw materials:

methanol

(2-amino-ethyl)-nitroso-amidosulfuric acid

2-(2-methoxyethyl)isoindoline-1,3-dione

2-methoxy-1-nitroethane

Downstream raw materials:

(1R,2R)-2-(2-Methoxy-ethylamino)-cyclohexanol

(N-(2-methoxyethyl))-2-chloroacetamide

N-(2-methoxyethyl)-2-<(benzotriazol-1-yl)methyl>-4-phenyl-5-methylpyrrole

(2-Methoxy-ethyl)-thiazol-2-yl-amine

Refernces

• 1、 Oliveira, Bruno L.,Stenton, Benjamin J.,Unnikrishnan,De Almeida, Cátia Rebelo,Conde, Jo?o,Negr?o, Magda,Schneider, Felipe S.S.,Cordeiro, Carlos,Ferreira, Miguel Godinho,Caramori, Giovanni F.,Domingos, Josiel B.,Fior, Rita,Bernardes, Gon?alo J. L.. "Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation". . p. 10869 - 10880. Retrieved 2020.
• 2、 Okuyama, Tadashi,Nagamatsu, Hiroaki,Kitano, Masakazu,Fueno, Takayuki. "Nucleophilic Catalysis of Hydrolysis of a Schiff Base by Amines. Intramolecular Catalysis of Transimination". . p. 1516 - 1521. Retrieved 1986.
• 3、 Tuchscherer, Andre,Schaarschmidt, Dieter,Schulze, Steffen,Hietschold, Michael,Lang, Heinrich. "Simple and efficient: Ethylene glycol isonitrile gold(I) chlorides for the formation and stabilization of gold nanoparticles". . p. 4421 - 4428. Retrieved 2011.
• 4、 -. "Preparation method of 2-methoxyethylamine". Paragraph 0029-0061. . Retrieved 2021/05/08.