5-Methoxy-N,N-diethyltryptamine

Base Information

• Chemical Name: 5-Methoxy-N,N-diethyltryptamine
• CAS No.: 1218-40-2
• Molecular Formula: C15H22N2O
• Molecular Weight: 246.34798
• Hs Code.: 2933990090
• UNII: 52HU7LM8HL
• DSSTox Substance ID: DTXSID30329130
• Nikkaji Number: J1.160.617B
• Wikipedia: 5-MeO-DET
• Wikidata: Q4639622
• Pharos Ligand ID: S5DHXZG8XRP7
• ChEMBL ID: CHEMBL342986
• Mol file: 1218-40-2.mol

Synonyms:5-Methoxy-N,N-diethyltryptamine;1218-40-2;N,N-diethyl-2-(5-methoxy-1H-indol-3-yl)ethanamine;5-MeO-DET;5-Methoxy-diethyltryptamine;52HU7LM8HL;1H-Indole-3-ethanamine, N,N-diethyl-5-methoxy-;UNII-52HU7LM8HL;CHEMBL342986;N,N-Diethyl-5-methoxy-1H-indole-3-ethanamine;Indole, 3-(2-(diethylamino)ethyl)-5-methoxy-;N,N-DIETHYL-5-METHOXYTRYPTAMINE;5-methoxy DET RM;NCIOpen2_005835;Oprea1_794512;SCHEMBL8892112;DTXSID30329130;BDBM50094673;PDSP1_000022;PDSP2_000022;STK370595;AKOS005446132;Q4639622;Diethyl-[2-(5-methoxy-1H-indol-3-yl)-ethyl]-amine

Chemical Property of 5-Methoxy-N,N-diethyltryptamine

Chemical Property:

• PSA: 28.26000
• LogP: 3.06080
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 246.173213330
• Heavy Atom Count: 18
• Complexity: 243

Purity/Quality:

99% ^*data from raw suppliers

5-MethoxyDET ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCC1=CNC2=C1C=C(C=C2)OC
• Uses: 5-Methoxy DET is used to prepare N1-benzenesulfonylgramine and N1-benzenesulfonylskatole derivatives as novel 5-HT6 receptor ligands.

Technology Process of 5-Methoxy-N,N-diethyltryptamine

There total 1 articles about 5-Methoxy-N,N-diethyltryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ diethyl-[2-(5-methoxy-indol-3-yl)-ethyl]-amine (1218-40-2)

Guidance literature:

<5-Methoxy-indol-3-yl>-glyoxylsaeure-diethylamid, LiAlH4, Tetrahydrofuran; Erwaermen;

Reference yield: 54.0%

diethyl-[2-(5-methoxy-indol-3-yl)-ethyl]-amine (1218-40-2) + benzenesulfonyl chloride (98-09-9) → [2-(1-benzenesulfonyl-5-methoxy-1H-indol-3-yl)-ethyl]-diethyl-amine

Guidance literature:

diethyl-[2-(5-methoxy-indol-3-yl)-ethyl]-amine; With sodium hydride; In N,N-dimethyl-formamide; Heating;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0960-894X(03)00612-7

Reference yield: 32.0%

diethyl-[2-(5-methoxy-indol-3-yl)-ethyl]-amine (1218-40-2) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → N-{4-[3-(2-diethylamino-ethyl)-5-methoxy-indole-1-sulfonyl]-phenyl}-acetamide

Guidance literature:

diethyl-[2-(5-methoxy-indol-3-yl)-ethyl]-amine; With sodium hydride; In N,N-dimethyl-formamide; Heating;

p-acetylaminobenzenesulfonyl chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0960-894X(03)00612-7