2-Methyl-chinolin-6-carbonsaeure-aMid

Base Information

• Chemical Name: 2-Methyl-chinolin-6-carbonsaeure-aMid
• CAS No.: 37535-43-6
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.2093
• Mol file: 37535-43-6.mol

Synonyms:2-Methyl-chinolin-6-carbonsaeure-aMid

Chemical Property of 2-Methyl-chinolin-6-carbonsaeure-aMid

Chemical Property:

• PSA: 84.39000
• LogP: 2.11770

Purity/Quality:

99% ^*data from raw suppliers

2-Methylquinoline-6-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-chinolin-6-carbonsaeure-aMid

There total 5 articles about 2-Methyl-chinolin-6-carbonsaeure-aMid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl 2-methyl-6-quinolinecarboxylate (108166-01-4) → 2-methylquinoline-6-carboxamide (37535-43-6)

Guidance literature:

With ammonium hydroxide; In methanol; at 45 ℃; for 12h;

Reference yield:

quinaldine-6-carboxylic acid (635-80-3) → 2-methylquinoline-6-carboxamide (37535-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanolic HCl

2: aqueous NH₃

With hydrogenchloride; ammonium hydroxide;

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 2-methylquinoline-6-carboxamide (37535-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 2 h / Reflux

1.2: 12.75 h

2.1: sulfuric acid / 12 h / 0 - 65 °C

3.1: ammonium hydroxide / methanol / 12 h / 45 °C

With hydrogenchloride; ammonium hydroxide; sulfuric acid; In methanol; water;

upstream raw materials:

ethyl 2-methylquinoline-6-carboxylate

quinaldine-6-carboxylic acid

methyl 2-methyl-6-quinolinecarboxylate

4-amino-benzoic acid

Refernces

• 1、 -. "NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES". . . Retrieved 2013/10/21.