635-80-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-6-quinolinecarboxylic acid is used as a key intermediate in the synthesis of arylpyrazolopyridine derivatives, which are known as monoacylglycerol lipase modulators. These modulators have potential applications in the treatment of various diseases, including metabolic disorders and inflammatory conditions, by regulating the activity of monoacylglycerol lipase enzymes.

InChI:InChI=1/C11H9NO2/c1-7-2-3-8-6-9(11(13)14)4-5-10(8)12-7/h2-6H,1H3,(H,13,14)

Upstream product

• 877-43-0 2,6-dimethylquinoline 
• 123-73-9 trans-Crotonaldehyde 
• 150-13-0 4-amino-benzoic acid 
• 123-73-9 crotonaldehyde 
• 108166-03-6 2-methylquinoline-6-carbaldehyde 
• 877-42-9 6-Bromo-2-methyl-quinoline 

Downstream Products

• 855763-77-8 ethyl 2-methylquinoline-6-carboxylate 
• 108166-01-4 methyl 2-methyl-6-quinolinecarboxylate 

Relevant academic research and scientific papers

Indenoquinaldine-Based Unsymmetrical Squaraine Dyes for Near-Infrared Absorption: Investigating the Steric and Electronic Effects in Dye-Sensitized Solar Cells

A series of near-infrared (NIR)-responsive unsymmetrical squaraine dyes (ISQ1–3) incorporating a fused indenoquinaldine-based donor have been designed and synthesized. C12 alkyl chains were incorporated at the sp3-hybridized carbon center of the indene unit of the indenoquinaldine in an out-of-plane orientation to control dye aggregation on the surface of titanium dioxide, and indole (ISQ1), benzo[e]indole (ISQ2), and quinoline (ISQ3) moieties were included as the donor component bearing the anchoring carboxy group to extend the absorption in the NIR region and to systematically study the effect of the electronic modification on the performance of dye-sensitized solar cells (DSSC). All the dyes exhibit intense absorption (?≥105 m?1 cm?1) in the NIR region, and the dye-adsorbed TiO2 films exhibit broad panchromatic absorption. The incident photon-to-current efficiency (IPCE) spectrum of the ISQ3-based DSSC device displays a panchromatic IPCE response up to 880 nm. Additionally, the ISQ3-sensitized device provides the best efficiency of 4.15 % with a short circuit current density (JSC) of 10.02 mA cm?2, open-circuit voltage (VOC) of 0.58 V, and fill factor (ff) of 72 % in the presence of 10 equivalents of 3α,7α-dihydroxy-5β-cholanic acid (CDCA). Electrochemical impedance spectroscopy analysis showed attenuated charge recombination in the ISQ3-sensitized DSSC, which contributes to its higher value of VOC compared with the other dyes.

Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid

The optimized molecular structure, vibrational frequencies, corresponding vibrational assignments of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid have been investigated experimentally and theoretically using Gaussian09 software package. Pot

NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC

The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES

The present invention provides compounds useful as C-met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of C-met kinase mediated diseases or disorders with them.

Unsymmetrical squaraines incorporating quinoline for near infrared responsive dye-sensitized solar cells

Two new unsymmetrical squaraines (WCH-SQ10 and WCH-SQ11), wherein the electron-rich 3,4-ethylenedioxy-thiophene conjugated fragment was linked unconventionally to the squaraine core and triphenyl amine donor, and carboxylic acid substituted quinoline was

Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

The structure-activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activ

BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE

Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.

Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines

Using the Kohonen neural network, the electrostatic potentials on the molecular surfaces of 14 styrylquinoline derivatives were drawn as comparative two-dimensional maps and compared with their known human immunodeficiency virus (HIV)-1 replication blocki