635-80-3

Basic information

• Product Name: 2-Methyl-6-quinolinecarboxylic acid
• Synonyms: 2-METHYL-6-QUINOLINECARBOXYLIC ACID;2-METHYLQUINOLINE-6-CARBOXYLIC ACID;Quinaldine-6-carboxylic acid;2-Methyl-6-quinolinecarboxylic acid ,97%;6-Quinolinecarboxylicacid, 2-Methyl-;6-Carboxy-2-methylquinoline, 6-Carboxy-2-methyl-1-azanaphthalene
• CAS NO: 635-80-3
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;Heterocyclic Compounds;Quinolines;quinoline;Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines
• Mol File: 635-80-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 347.6 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /Solid
• Density: 1.285 g/cm³
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.13±0.30(Predicted)
• CAS DataBase Reference: 2-Methyl-6-quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-6-quinolinecarboxylic acid(635-80-3)
• EPA Substance Registry System: 2-Methyl-6-quinolinecarboxylic acid(635-80-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 635-80-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

2-Methylquinoline-6-carboxylic Acid is a preparation of arylpyrazolopyridine derivative as monoacylglycerol lipase modulators.

InChI:InChI=1/C11H9NO2/c1-7-2-3-8-6-9(11(13)14)4-5-10(8)12-7/h2-6H,1H3,(H,13,14)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 123-73-9 crotonaldehyde 
• 877-42-9 6-Bromo-2-methyl-quinoline 
• 108166-03-6 2-methylquinoline-6-carbaldehyde 
• 123-73-9 trans-Crotonaldehyde 
• 877-43-0 2,6-dimethylquinoline 

Downstream Products

• 855763-77-8 ethyl 2-methylquinoline-6-carboxylate 
• 1618648-12-6 [4-({[1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carbonyl]amino}methyl)benzyl]carbamic acid tert-butyl ester 
• 1618699-45-8 1-(2-methylquinolin-6-ylmethyl)-1H-pyrazole-4-carboxylic acid 4-aminomethylbenzylamide 

Relevant articles and documents

Indenoquinaldine-Based Unsymmetrical Squaraine Dyes for Near-Infrared Absorption: Investigating the Steric and Electronic Effects in Dye-Sensitized Solar Cells

A series of near-infrared (NIR)-responsive unsymmetrical squaraine dyes (ISQ1–3) incorporating a fused indenoquinaldine-based donor have been designed and synthesized. C12 alkyl chains were incorporated at the sp3-hybridized carbon center of the indene unit of the indenoquinaldine in an out-of-plane orientation to control dye aggregation on the surface of titanium dioxide, and indole (ISQ1), benzo[e]indole (ISQ2), and quinoline (ISQ3) moieties were included as the donor component bearing the anchoring carboxy group to extend the absorption in the NIR region and to systematically study the effect of the electronic modification on the performance of dye-sensitized solar cells (DSSC). All the dyes exhibit intense absorption (?≥105 m?1 cm?1) in the NIR region, and the dye-adsorbed TiO2 films exhibit broad panchromatic absorption. The incident photon-to-current efficiency (IPCE) spectrum of the ISQ3-based DSSC device displays a panchromatic IPCE response up to 880 nm. Additionally, the ISQ3-sensitized device provides the best efficiency of 4.15 % with a short circuit current density (JSC) of 10.02 mA cm?2, open-circuit voltage (VOC) of 0.58 V, and fill factor (ff) of 72 % in the presence of 10 equivalents of 3α,7α-dihydroxy-5β-cholanic acid (CDCA). Electrochemical impedance spectroscopy analysis showed attenuated charge recombination in the ISQ3-sensitized DSSC, which contributes to its higher value of VOC compared with the other dyes.

NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC

The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

Unsymmetrical squaraines incorporating quinoline for near infrared responsive dye-sensitized solar cells

Two new unsymmetrical squaraines (WCH-SQ10 and WCH-SQ11), wherein the electron-rich 3,4-ethylenedioxy-thiophene conjugated fragment was linked unconventionally to the squaraine core and triphenyl amine donor, and carboxylic acid substituted quinoline was