(1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate

Base Information

Chemical Name:(1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate
CAS No.:929693-31-2
Molecular Formula:C15H28N2O6S
Molecular Weight:364.463
Hs Code.:
Mol file:929693-31-2.mol

Synonyms:(1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate;Carbamic acid, N-[(1R,2R,5S)-5-[(dimethylamino)carbonyl]-2-[(methylsulfonyl)oxy]cyclohexyl]-, 1,1-dimethylethyl ester;4-(dimethylcarbamoyl)cyclohexyl methanesulfonate

Suppliers and Price of (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 13 raw suppliers

Chemical Property of (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate

Chemical Property:

Boiling Point:546.0±50.0 °C(Predicted)
PKA:11.09±0.60(Predicted)
PSA：110.39000
Density:1.21±0.1 g/cm3(Predicted)
LogP:2.58450

Purity/Quality:: 98%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-(tert-Butoxycarbonyl) Methanesulfonate Edoxaban is an impurity of Edoxaban (E555520). Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.

Technology Process of (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate

There total 10 articles about (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929693-30-1
(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide

: 124-63-0
methanesulfonyl chloride

: 929693-31-2
{(1R,2R,4S)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexyl}methanesulfonate

Guidance literature:: With triethylamine; In 4-methyl-2-pentanone; at 20 ℃; for 1h;

Reference yield:

: tert-butyl {(1R,2R,5S)-5-[(dimethylamino)carbonyl]-2-hydroxycyclohexylcarbonyl}carbamate

: 124-63-0
methanesulfonyl chloride

: 929693-31-2
{(1R,2R,4S)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexyl}methanesulfonate

Guidance literature:: With triethylamine; at 20 ℃; for 1h;

Reference yield:

: 929693-36-7
(1S,3R,4R)-3-amino-4-hydroxy-N,N-dimethyl cyclohexanecarboxamide

: 929693-31-2
{(1R,2R,4S)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexyl}methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2 h / 20 - 40 °C

2: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C

With triethylamine; sodium hydroxide; In 4-methyl-2-pentanone (MIBK); water;