Methoxyacetylfentanyl

Base Information

• Chemical Name: Methoxyacetylfentanyl
• CAS No.: 101345-67-9
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.477
• UNII: U7IAB3Z3V4
• DSSTox Substance ID: DTXSID001036741
• Wikipedia: Methoxyacetylfentanyl
• ChEMBL ID: CHEMBL1740467
• Mol file: 101345-67-9.mol

Synonyms:Methoxyacetylfentanyl;Methoxy-acetyl-fentanyl;101345-67-9;U7IAB3Z3V4;2-methoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide;UNII-U7IAB3Z3V4;N-(1-(2-Phenylethyl)-4-piperidinyl)-2-methoxyacetanilide;2-methoxy-N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide;Acetamide, 2-methoxy-N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)-;2-Methoxy-N-phenylmethoxyacetylfentanyl-N-(1-(2-phenylethyl)-4-piperidinyl)acetamide;2-methoxy-N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]acetamide;METHOXYACETYL FENTANYL;Oprea1_864562;AE-641/30153053;CHEMBL1740467;SCHEMBL18623778;DTXSID001036741;MFCD01237600;AKOS005066113;CCG-276004

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Chemical Property of Methoxyacetylfentanyl

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 352.215078140
• Heavy Atom Count: 26
• Complexity: 408

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Methoxyacetylfentanyl

There total 5 articles about Methoxyacetylfentanyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Methoxyacetic anhydride (19500-95-9) + (1-Phenethyl-piperidin-4-yl)-phenyl-amine (21409-26-7) → N-(1-(2-phenylethyl)-4-piperidinyl)-2-(methoxy)acetanilide (101345-67-9)

Guidance literature:

In benzene; for 6h; Heating;

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → N-(1-(2-phenylethyl)-4-piperidinyl)-2-(methoxy)acetanilide (101345-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Molecular sieve

2: sodium tetrahydroborate

3: sodium tetrahydroborate

With sodium tetrahydroborate;

DOI:10.1248/bpb.b20-00780

Reference yield:

aniline (62-53-3) → N-(1-(2-phenylethyl)-4-piperidinyl)-2-(methoxy)acetanilide (101345-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Molecular sieve

2: sodium tetrahydroborate

3: sodium tetrahydroborate

With sodium tetrahydroborate;

DOI:10.1248/bpb.b20-00780

upstream raw materials:

Methoxyacetic anhydride

(1-Phenethyl-piperidin-4-yl)-phenyl-amine

1-(2-phenylethyl)-4-piperidinone

aniline