4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL

Base Information

• Chemical Name: 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL
• CAS No.: 1263374-32-8
• Molecular Formula: C7H12N2O
• Molecular Weight: 140.185
• Hs Code.: 2932999099
• Mol file: 1263374-32-8.mol

Synonyms:4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL;4-(AMinoMethyl)tetrahydro-2H-pyran-4-carbonitrile;4-(aminomethyl)-tetrahydro-2H-pyran-4-carbonitrile hydrochloride

Chemical Property of 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL

Chemical Property:

• Boiling Point: 281.0±25.0 °C(Predicted)
• PKA: 10.01±0.29(Predicted)
• PSA: 59.04000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 0.96578

Purity/Quality:

95% ^*data from raw suppliers

4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile Is used in the synthesis of CDK9 inhibitors.

Technology Process of 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL

There total 2 articles about 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dihydro-2H-pyran-4,4(3H)-dicarbonitrile (111511-90-1) → 4-(aminomethyl)tetrahydro-2H-pyran-4-carbonitrile (1263374-32-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 4h;

Reference yield:

dihydro-2H-pyran-4,4(3H)-dicarbonitrile (111511-90-1) → 4-(aminomethyl)tetrahydro-2H-pyran-4-carbonitrile (1263374-32-8)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 20 ℃; for 4h;

Reference yield:

5-chloro-2-fluoro-4-iodopyridine (659731-48-3) + 4-(aminomethyl)tetrahydro-2H-pyran-4-carbonitrile (1263374-32-8) → 4-(((5-chloro-4-iodopyridin-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:

In dimethyl sulfoxide; at 100 ℃; for 8h;

upstream raw materials:

dihydro-2H-pyran-4,4(3H)-dicarbonitrile

Downstream raw materials:

4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile