4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Base Information

Chemical Name:4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile
CAS No.:1263374-47-5
Molecular Formula:C₁₉H₂₀FN₃O₂
Molecular Weight:341.385
Hs Code.:

Synonyms:4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

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Chemical Property of 4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

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Technology Process of 4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

There total 3 articles about 4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1263374-46-4
4-((3,6-difluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

: 100-51-6,185532-71-2
benzyl alcohol

: 1263374-47-5
4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:: benzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

4-((3,6-difluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; In N,N-dimethyl-formamide; mineral oil; at 90 ℃; for 5h;

Reference yield:

: 111511-90-1
dihydro-2H-pyran-4,4(3H)-dicarbonitrile

: 1263374-47-5
4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; sodium tetrahydroborate / 4 h / 20 °C

2.1: triethylamine / dimethyl sulfoxide / 18 h / 105 °C / Sealed glass bomb

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

3.2: 5 h / 90 °C

With sodium tetrahydroborate; ethanol; sodium hydride; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1263374-32-8
4-(aminomethyl)tetrahydro-2H-pyran-4-carbonitrile

: 1263374-47-5
4-((6-(benzyloxy)-3-fluoropyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dimethyl sulfoxide / 18 h / 105 °C / Sealed glass bomb

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 5 h / 90 °C

With sodium hydride; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;