OFLOXACIN

Base Information

• Chemical Name: OFLOXACIN
• CAS No.: 83380-47-6
• Molecular Formula: C₁₈H₂₀FN₃O₄
• Molecular Weight: 361.373
• Mol file: 83380-47-6.mol

Synonyms:TARIVID;AKOS NCG1-0050;KFLOXACIN

Chemical Property of OFLOXACIN

Chemical Property:

• Vapor Pressure: 6.7E-14mmHg at 25°C
• Melting Point: 218℃
• Boiling Point: 571.5°C at 760 mmHg
• Flash Point: 299.4°C
• PSA: 75.01000
• Density: 1.48g/cm³
• LogP: 1.54690
• Storage Temp.: 2-8°C

Purity/Quality:

>99% ^*data from raw suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Therapeutic Function: Antibacterial

Technology Process of OFLOXACIN

There total 75 articles about OFLOXACIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

1-methyl-piperazine (109-01-3) + 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid (82419-35-0) → ofloxacin (82419-36-1,83380-47-6)

Guidance literature:

With potassium hydroxide; In water; at 60 ℃; for 6h; Time; Solvent;

Reference yield: 87.9%

1-methyl-piperazine (109-01-3) + ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate (82419-34-9) → ofloxacin (82419-36-1,83380-47-6)

Guidance literature:

With acetic acid; In water; N,N-dimethyl-formamide; at 70 - 105 ℃; for 10h; Temperature; Reagent/catalyst; Solvent;

Reference yield:

1-methyl-piperazine (109-01-3) + C17H14BF2NO8 → ofloxacin (82419-36-1,83380-47-6)

Guidance literature:

1-methyl-piperazine; C₁₇H₁₄BF₂NO₈; With triethylamine; In dichloromethane; at 40 ℃; for 1.5h; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 0 - 30 ℃; for 3h;

upstream raw materials:

1-methyl-piperazine

9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid acetoxymethyl ester

8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 1-acetoxy-ethyl ester

Downstream raw materials:

OFL-TBBQ

Refernces

• 1、 -. "Preparation method of levofloxacin and intermediates thereof". . . Retrieved 2021/03/30.
• 2、 Ma, Qianyun,Cong, Wei,Liu, Ye,Geng, Zikai,Lin, Ying,Wang, Zhaokun. "Experimental and computational study on the enantioseparation of four chiral fluoroquinolones by capillary electrophoresis with sulfated-β-cyclodextrin as chiral selector". . p. 549 - 557. Retrieved 2021/07/20.