FMOC-D-LYS-OALL HCL

Base Information

• Chemical Name: FMOC-D-LYS-OALL HCL
• CAS No.: 1272754-92-3
• Molecular Formula: C24H29ClN2O4
• Molecular Weight: 444.95
• Mol file: 1272754-92-3.mol

Synonyms:N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LYSINE ALLYL ESTER HYDROCHLORIDE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-LYSINE ALLYL ESTER HYDROCHLORIDE;FMOC-L-LYS-OALL HCL;FMOC-D-LYS-OALL HCL

Chemical Property of FMOC-D-LYS-OALL HCL

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Fmoc-D-Lys-OAll*HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-D-LYS-OALL HCL

There total 3 articles about FMOC-D-LYS-OALL HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Fmoc-Lys-OH (105047-45-8) + allyl alcohol (107-18-6) → Nα-(9-fluorenylmethoxycarbonyl)-L-lysine allyl ester hydrochloride (1272754-92-3,815619-80-8)

Guidance literature:

With thionyl chloride; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/acs.bioconjchem.6b00393

Reference yield: 97.4%

(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(tert-butoxycarbonyl amino) hexanoate (213667-59-5) → Nα-(9-fluorenylmethoxycarbonyl)-L-lysine allyl ester hydrochloride (1272754-92-3,815619-80-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 1h;

Reference yield:

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → Nα-(9-fluorenylmethoxycarbonyl)-L-lysine allyl ester hydrochloride (1272754-92-3,815619-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.5 percent / 4-(dimethylamino)pyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 0 °C

2: 97.4 percent / HCl / dioxane / 1 h / 25 °C

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

upstream raw materials:

(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(tert-butoxycarbonyl amino) hexanoate

Fmoc-Lys(tert-butoxycarbonyl)

Fmoc-Lys-OH

allyl alcohol