ethyl 7-chloro-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 7-chloro-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate
• CAS No.: 1335053-81-0
• Molecular Formula: C₁₁H₁₁ClN₂O₂
• Molecular Weight: 238.674
• Hs Code.: 2933990090
• Mol file: 1335053-81-0.mol

Synonyms:ethyl 7-chloro-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate;ethyl 7-chloro-2-methylH-imidazo[1,2-a]pyridine-3-carboxylate

Chemical Property of ethyl 7-chloro-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

Chemical Property:

• PSA: 43.60000
• LogP: 2.47280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 7-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 7-chloro-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

There total 4 articles about ethyl 7-chloro-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-Amino-4-chloropyridine (19798-80-2) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 7-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1335053-81-0)

Guidance literature:

In ethanol; at 120 ℃; for 0.333333h; Microwave irradiation;

DOI:10.3987/COM-15-13299

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 7-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1335053-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / water / 1.5 h / Reflux

2: 3 h / Reflux

With N-Bromosuccinimide; In water;

DOI:10.1111/cbdd.13739

Reference yield:

2-Amino-4-chloropyridine (19798-80-2) → ethyl 7-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1335053-81-0)

Guidance literature:

Microwave irradiation;

DOI:10.1016/j.ejmech.2019.06.038

upstream raw materials:

2-Amino-4-chloropyridine

ethyl 2-chloro-3-oxo-butyrate

ethyl acetoacetate

ethyl 2-bromoacetoacetate