8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate

Base Information

Chemical Name:8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate
CAS No.:54725-48-3
Molecular Formula:C17H21NO3
Molecular Weight:287.35
Hs Code.:
Mol file:54725-48-3.mol

Synonyms:8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate

Suppliers and Price of 8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate

Chemical Property:

PSA：49.77000
LogP:1.64480

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate

There total 10 articles about 8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol α-(hydroxymethyl)benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 51-34-3,138-12-5,64069-63-2,124917-17-5
scopolamine

: 22150-33-0,54725-48-3,61616-97-5
(αS)-α-(hydroxymethyl)benzeneacetic acid (endo)-8-methyl8-azabicyclo[3.2.1]oct-6-en-3-yl ester

Guidance literature:: With ethanol; copper; zinc;
DOI:10.1016/j.bmcl.2003.09.081

Reference yield: 88.0%

: 152612-85-6
scopolamine hydrobromide trihydrate

: 22150-33-0,54725-48-3,61616-97-5
(αS)-α-(hydroxymethyl)benzeneacetic acid (endo)-8-methyl8-azabicyclo[3.2.1]oct-6-en-3-yl ester

Guidance literature:: With zinc/copper couple; In ethanol; for 16h; Reflux;

Reference yield: 85.0%

: 20513-09-1
(1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol

: 183626-74-6
(αS)-α-(acetoxymethyl)benzeneacetyl chloride

: 22150-33-0,54725-48-3,61616-97-5
(αS)-α-(hydroxymethyl)benzeneacetic acid (endo)-8-methyl8-azabicyclo[3.2.1]oct-6-en-3-yl ester

Guidance literature:: (1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol; With toluene-4-sulfonic acid; In diethyl ether; at 20 ℃; for 0.666667h;

(αS)-α-(acetoxymethyl)benzeneacetyl chloride; In benzene; at 82 ℃; for 2.5h;

With hydrogenchloride; In benzene; at 20 ℃; for 12h;
DOI:10.1002/hlca.200390258