H2N-PEG2-Propyne

Base Information

Chemical Name:H2N-PEG2-Propyne
CAS No.:944561-44-8
Molecular Formula:C7H13NO2
Molecular Weight:143.186
Hs Code.:
Mol file:944561-44-8.mol

Synonyms:H2N-PEG2-Propyne;2-[2-(2-Propynyloxy)ethoxy]ethylamine;Propargyl-PEG2-amine

Suppliers and Price of H2N-PEG2-Propyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T)
1g
$ 97.00

TCI Chemical
2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T)
5g
$ 343.00

purepeg
HC≡C-CH2-PEG2-NH2 min.95%
5 g
$ 458.00

Crysdot
2-[2-(2-Propynyloxy)ethoxy]ethylamine 95+%
5g
$ 226.00

Crysdot
2-[2-(2-Propynyloxy)ethoxy]ethylamine 95+%
10g
$ 441.00

Crysdot
2-[2-(2-Propynyloxy)ethoxy]ethylamine 95+%
25g
$ 871.00

CHESS?
2-(2-Prop-2-ynyloxy-ethoxy)-ethylamine 98
5 g
$ 24000.00

ChemScene
Propargyl-PEG2-amine 96.52%
10g
$ 373.00

ChemScene
Propargyl-PEG2-amine 96.52%
5g
$ 214.00

ChemScene
Propargyl-PEG2-amine 96.52%
25g
$ 721.00

Total 24 raw suppliers

Chemical Property of H2N-PEG2-Propyne

Chemical Property:

Refractive Index:1.4590 to 1.4630
Boiling Point:213.8±20.0 °C(Predicted)
PKA:8.72±0.10(Predicted)
PSA：44.48000
Density:0.992±0.06 g/cm3(Predicted)
LogP:0.31180
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Propargyl-PEG2-amine is a crosslinker that is reactive with NHS esters, carbonyls (carboxylic acid, ketone, aldehyde). The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reaction to form a stable triazole linkage.
Uses 2-[2-(2-Propynyloxy)ethoxy]ethylamine is used in preparation of RSV F protein inhibitors conjugated to Fc variants and albumins.

Technology Process of H2N-PEG2-Propyne

There total 7 articles about H2N-PEG2-Propyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 869310-84-9
tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate

: 944561-44-8,956348-61-1
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jacs.0c06793

Reference yield: 86.0%

: 1245006-63-6
3-(2-(2-azidoethoxy)ethoxy)prop-1-yne

: 944561-44-8,956348-61-1
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

Guidance literature:: 3-(2-(2-azidoethoxy)ethoxy)prop-1-yne; In tetrahydrofuran; at 20 ℃; for 1152h; polymer-supported triphenylphosphine

With water; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.3390/molecules180911639

Reference yield:

: 106-96-7
propargyl bromide

: 929-06-6
2-(2-Aminoethoxy)ethanol

: 944561-44-8,956348-61-1
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

Guidance literature:: 2-(2-Aminoethoxy)ethanol; With di-tert-butyl dicarbonate; sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 24h;

propargyl bromide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 4h; Cooling with ice;