Ethanol, 2-(2-(2-propynyloxy)ethoxy)-

Base Information

• Chemical Name: Ethanol, 2-(2-(2-propynyloxy)ethoxy)-
• CAS No.: 7218-43-1
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• Hs Code.: 2909498090
• European Community (EC) Number: 230-612-5
• DSSTox Substance ID: DTXSID50222513
• Nikkaji Number: J60.709F
• Wikidata: Q83100768
• Mol file: 7218-43-1.mol

Synonyms:7218-43-1;Ethanol, 2-(2-(2-propynyloxy)ethoxy)-;2-(2-prop-2-ynoxyethoxy)ethanol;Propargyl-PEG2-OH;2-(2-(prop-2-ynyloxy)ethoxy)ethanol;2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL;2-[2-(2-Propynyloxy)ethoxy]ethanol;Diethylene Glycol Mono(2-propyn-1-yl) Ether;MFCD00053353;2-(2-(Propyn-2-yloxy)ethoxy)ethanol;Ethanol, 2-[2-(2-propynyloxy)ethoxy]-;EINECS 230-612-5;ethanol,2-(2-(2-propynyloxy)ethoxy)-;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-ol;2-[2-(PROP-2-YN-1-YLOXY)ETHOXY]ETHAN-1-OL;2-[2-(Propyn-2-yloxy)ethoxy]ethanol;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanol;2-[2-(PROP-2-YN-1-YLOXY)ETHOXY]ETHANOL;Propyne-PEG2-HO;Propyne-PEG2-OH;C#CCOCCOCCO;starbld0015794;SCHEMBL9511;LCZC1966;HUSDTFBXUYBZJD-UHFFFAOYSA-;DTXSID50222513;2(2-Ethoxyethoxy)ethanol, 98+%;HC identical withC-CH2-PEG2-OH;2-[2-(Propargyloxy)ethoxy]ethanol;BCP33460;ZB0911;AKOS025402678;2-(2-Prop-2-ynyloxy-ethoxy)-ethanol;AB02237;2-[2-(2-Propyn-1-yloxy)ethoxy]ethanol;AM804281;AS-19830;BP-20675;SY051003;HY-130541;CS-0108947;D4580;HC inverted exclamation markOC-CH2-PEG2-OH;EN300-7348271;A914207;J-505427;2-(2-(Prop-2-ynyloxy)ethoxy)ethanol

Chemical Property of Ethanol, 2-(2-(2-propynyloxy)ethoxy)-

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.4570 to 1.4610
• Boiling Point: 225.6°Cat760mmHg
• PKA: 14.35±0.10(Predicted)
• Flash Point: 90.3°C
• PSA: 38.69000
• Density: 1.044g/cm³
• LogP: -0.35490
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Acetone, Chloroform, Ethyl Acetate
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 144.078644241
• Heavy Atom Count: 10
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C#CCOCCOCCO
• Description: Propargyl-PEG3-alcohol consists of a hydroxyl group and a propargyl group. The propargyl group reacts with azide compounds in copper catalyzed azide-alkyne Click Chemistry to form a triazole linkage.
• Uses: 2-[2-(2-Propynyloxy)ethoxy]ethanol is a reactant used in the preparation of divalent ligands based on 3-deoxy-4-thiolactose as inhibitors of E. coli β-galactosidase.

Technology Process of Ethanol, 2-(2-(2-propynyloxy)ethoxy)-

There total 4 articles about Ethanol, 2-(2-(2-propynyloxy)ethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

propargyl bromide (106-96-7) + diethylene glycol (111-46-6) → 2-(2-(prop-2-ynyloxy)ethoxy)ethanol (7218-43-1)

Guidance literature:

diethylene glycol; With potassium tert-butylate; In tetrahydrofuran; at 0 - 25 ℃; for 0.5h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja403323y

Reference yield:

3-(2-(2-(vinyloxy)ethoxy)ethoxy)prop-1-yne (6188-74-5) → 2-(2-(prop-2-ynyloxy)ethoxy)ethanol (7218-43-1)

Guidance literature:

With hydrogenchloride;

Reference yield:

oxirane (75-21-8,99932-75-9) + propargyl alcohol (107-19-7) → 2-(2-(prop-2-ynyloxy)ethoxy)ethanol (7218-43-1)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

oxirane

propargyl alcohol

3-(2-(2-(vinyloxy)ethoxy)ethoxy)prop-1-yne

propargyl bromide

Downstream raw materials:

4-[7-hydroxy-2,5-dioxaheptyl]-1-[3-(2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol-N-yl)-propyl]-1H-[1,2,3]-triazole

4-methylbenzene sulfonic acid 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl

3-((2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-(3-(2-(2-hydroxyethoxy)ethoxy)prop-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

1-bromo-2-[2-(prop-2-yn-1-yloxy)ethoxy]ethane