3-METHYL-1H-PYRROLO[3,2-C]PYRIDINE

Base Information

• Chemical Name: 3-METHYL-1H-PYRROLO[3,2-C]PYRIDINE
• CAS No.: 22930-75-2
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Hs Code.: 2933990090
• Mol file: 22930-75-2.mol

Synonyms:3-METHYL-1H-PYRROLO[3,2-C]PYRIDINE;3-Methyl-5-azaindole;3-Methyl-5-azaindole 3-Methyl-1H-pyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine, 3-methyl-

Chemical Property of 3-METHYL-1H-PYRROLO[3,2-C]PYRIDINE

Chemical Property:

• Melting Point: 138-140 °C
• Boiling Point: 286.4±20.0 °C(Predicted)
• PKA: 15.50±0.40(Predicted)
• PSA: 28.68000
• Density: 1.186±0.06 g/cm3(Predicted)
• LogP: 1.87130
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-methyl-1H-pyrrolo[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-1H-PYRROLO[3,2-C]PYRIDINE

There total 3 articles about 3-METHYL-1H-PYRROLO[3,2-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-methyl-2-trimethylsilyl-1H-pyrrolo[3,2-c]pyridine (868173-90-4) → 3-methyl-1H-pyrrolo[3,2-c]pyridine (22930-75-2)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1007/s00044-004-0121-8

Reference yield:

3-iodopyridin-4-amine (88511-27-7) → 3-methyl-1H-pyrrolo[3,2-c]pyridine (22930-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃; LiCl / Pd(dppf)Cl₂*C₂H₂Cl₂ / dimethylformamide / 120 °C

2: 93 percent / NaOH / ethanol / Heating

With sodium hydroxide; sodium carbonate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/s00044-004-0121-8

Reference yield:

→ 3-methyl-1H-pyrrolo[3,2-c]pyridine (22930-75-2)

Guidance literature:

Verb.9, Dimethylsulphoniummethylid;

DOI:10.1016/S0040-4020(01)97027-9

upstream raw materials:

3-methyl-2-trimethylsilyl-1H-pyrrolo[3,2-c]pyridine

3-iodopyridin-4-amine

Downstream raw materials:

N-[4-(3-methyl-pyrrolo[3,2-c]pyridine-1-sulfonyl)-phenyl]-acetamide

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