4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide

Base Information

• Chemical Name: 4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide
• CAS No.: 1073160-19-6
• Molecular Formula: C13H10ClF3N4O
• Molecular Weight: 330.697
• Mol file: 1073160-19-6.mol

Synonyms:4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide

Chemical Property of 4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide

Chemical Property:

• PSA: 66.91000
• LogP: 3.71590

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide

There total 5 articles about 4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-amino-N-methyl-benzamide (6274-22-2) + 2,4-dichloro-5-trifluoromethylpyrimidine (3932-97-6) → 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-methylbenzamide (1073160-19-6)

Guidance literature:

2,4-dichloro-5-trifluoromethylpyrimidine; With zinc dibromide; In dichloromethane; tert-butyl alcohol; at 0 ℃; for 0.5h;

4-amino-N-methyl-benzamide; With triethylamine; In dichloromethane; tert-butyl alcohol; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2021.113573

Reference yield: 42.3%

4-amino-N-methylbenzamide trifluoroacetate + 2,4-dichloro-5-trifluoromethylpyrimidine (3932-97-6) → 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-methylbenzamide (1073160-19-6)

Guidance literature:

2,4-dichloro-5-trifluoromethylpyrimidine; With zinc dibromide; In 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 0.5h; Cooling with ice;

4-amino-N-methylbenzamide trifluoroacetate; With triethylamine; In 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃;

Reference yield:

4-nitro-benzoic acid (62-23-7) → 4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-methylbenzamide (1073160-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride / 3 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

3.1: tin(II) chloride dihdyrate / ethyl acetate / 3 h / Reflux

4.1: zinc dibromide / dichloromethane; tert-butyl alcohol / 0.5 h / 0 °C

4.2: 0 - 20 °C

With oxalyl dichloride; tin(II) chloride dihdyrate; triethylamine; zinc dibromide; In dichloromethane; ethyl acetate; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2021.113573

upstream raw materials:

4-amino-N-methyl-benzamide

2,4-dichloro-5-trifluoromethylpyrimidine

N-methyl-4-nitrobenzamide

4-nitro-benzoic acid