N-Methyl-4-Nitro-Benzamide

Base Information

• Chemical Name: N-Methyl-4-Nitro-Benzamide
• CAS No.: 2585-23-1
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.163
• Hs Code.: 2924299090
• Mol file: 2585-23-1.mol

Synonyms:Benzamide,N-methyl-p-nitro- (6CI,7CI,8CI);N-Methyl-4-nitrobenzamide;N-Methyl-p-nitrobenzamide;NSC 406838;

Chemical Property of N-Methyl-4-Nitro-Benzamide

Chemical Property:

• Vapor Pressure: 4.65E-06mmHg at 25°C
• Melting Point: 219 °C
• Refractive Index: 1.569
• Boiling Point: 382.6 °C at 760 mmHg
• PKA: 13?+-.0.46(Predicted)
• Flash Point: 185.2 °C
• PSA: 74.92000
• Density: 1.272 g/cm³
• LogP: 1.86850

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl-4-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-4-Nitro-Benzamide

There total 29 articles about N-Methyl-4-Nitro-Benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methylamine (74-89-5) → N-methyl-4-nitrobenzamide (2585-23-1)

Guidance literature:

In chloroform; for 1h;

DOI:10.1021/jo00389a006

Reference yield: 90.0%

4-nitro-benzoyl chloride (122-04-3) + methylamine (74-89-5) → N-methyl-4-nitrobenzamide (2585-23-1)

Guidance literature:

In 1,4-dioxane; water; at 0 - 20 ℃; for 0.5h;

DOI:10.1134/S1070428020050127

Reference yield: 90.0%

methylamine (74-89-5) + 4-nitro-benzoic acid (62-23-7) → N-methyl-4-nitrobenzamide (2585-23-1)

Guidance literature:

With silica gel; toluene-4-sulfonic acid; for 0.0333333h; microwave irradiation;

upstream raw materials:

4-nitro-benzoyl chloride

methylamine

acetic anhydride

N-(p-nitrobenzylidene)methylamine N-oxide

Downstream raw materials:

4-amino-N-methyl-benzamide

1-methyl-5-(4-nitrophenyl)-1H-tetrazole

N-methyl-4-nitro-N-nitrosobenzamide

3-methyl-2-(4-nitro-phenyl)-4,6-dioxo-5-phenyl-5,6-dihydro-4H-[1,3]oxazinium betaine