Apremilast, (+/-)-

Base Information

Chemical Name:Apremilast, (+/-)-
CAS No.:253168-86-4
Molecular Formula:C22H24N2O7S
Molecular Weight:460.508
Hs Code.:
UNII:N5UK68MGDZ
Wikidata:Q27284588
NCI Thesaurus Code:C72703
ChEMBL ID:CHEMBL475165
Mol file:253168-86-4.mol

Synonyms:253168-86-4;Apremilast, (+/-)-;N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;Apremilast (+/-)-form [MI];UNII-N5UK68MGDZ;N5UK68MGDZ;N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide;CHEMBL475165;Acetamide, N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-;(+/-)-apremilast;MFCD18782607;n-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-4-yl)acetamide;SCHEMBL302671;IMOZEMNVLZVGJZ-UHFFFAOYSA-N;HMS3653D04;BDBM50603812;AKOS026750626;SB16492;2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;NCGC00389674-01;(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;CS-15200;SY046906;CS-0009722;FT-0700081;C13157;Q27284588;2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetamidoisoindoline-1,3-dione;2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1.3-dione;2-[1-(3-Ethoxy4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione;N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide;(S)-4-Acetylamino-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]isoindoline-1,3-dione

Suppliers and Price of Apremilast, (+/-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

aablocks
N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide 98%
250mg
$ 700.00

aablocks
N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide 98%
100mg
$ 436.00

Total 13 raw suppliers

Chemical Property of Apremilast, (+/-)-

Chemical Property:

Boiling Point:741.3±60.0 °C(Predicted)
PKA:14.01±0.20(Predicted)
PSA：127.46000
Density:1.381±0.06 g/cm3(Predicted)
LogP:3.52590
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:460.13042228
Heavy Atom Count:32
Complexity:825

Purity/Quality:

99% ^*data from raw suppliers

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

Technology Process of Apremilast, (+/-)-

There total 8 articles about Apremilast, (+/-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%