608141-43-1

Basic information

• Product Name: (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
• Synonyms: (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt;N-Acetyl-L-leucine compound with (alphaS)-3-ethoxy-4-methoxy-alpha-[(methylsulfonyl)methyl]benzenemethanamine;(2S)-2-acetamido-4-methylpentanoate;[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium;(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine acetyl-L-leucinate;(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethylamine N-acetyl L-leucine salt;(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (S)-2-acetamido-4-methylpentanoate
• CAS NO: 608141-43-1
• Molecular Formula: C₈H₁₅NO₃*C₁₂H₁₉NO₄S
• Molecular Weight: 446.55816
• EINECS: -0
• Mol File: 608141-43-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt(608141-43-1)
• EPA Substance Registry System: (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt(608141-43-1)

Safety Data

• Hazardous Substances Data: 608141-43-1(Hazardous Substances Data)

Usage

General Description

The chemical "(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt" is a compound consisting of a amine group connected to a sulfur-containing methylsulfonyl group, with an acetyl-L-leucine salt moiety. It is classified as a salt and is likely to be a crystalline solid with a specific arrangement of atoms. The compound may have potential applications in the pharmaceutical or chemical industries, although further research would be required to determine its specific uses and properties.

Upstream product

• 31526-71-3 3-ethoxy-4-methoxy-acetophenone 
• 6100-74-9 3-hydroxy-4-methoxyacetophenone 
• 52849-52-2 1-Bromo-3-ethoxy-4-methoxybenzene 
• 1131-52-8 3-ethoxy-4-methoxybenzaldehyde 
• 97966-31-9 3-ethoxy-4-methoxybenzoic acid methyl ester 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 
• 1188-21-2 N-Ac-Leu 
• 253168-94-4 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine 
• 60758-86-3 3-ethoxy-4-methoxybenzenecarbonitrile 
• 1450657-24-5 (R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol 
• 1450657-28-9 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one 
• 1450657-31-4 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine 
• 1450657-43-8 (S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene 

Downstream Products

• 635705-72-5 4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 608141-41-9 Apremilast 
• 253168-86-4 rac-Apremilast 
• 1227368-31-1 (1S)-7-nitro-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethyl]isoindolin-1-one 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 
• 635705-76-9 7-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]isoindolin-1-one 

Relevant articles and documents

METHODS FOR THE TREATMENT OF OBESITY USING APREMILAST

Methods of treating, managing or preventing obesity and overweight are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.

NOVEL PROCESS FOR THE PREPARATION OF 1-(3-ETHOXY-4-METHOXY-PHENYL)-2-METHYLSULFONYL-ETHANAMINE

The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C4)haloalkyl, -O(C1-C4)alkyl, or –O-benzyl, and L is a leaving group.

Synthesis process of apremilast intermediate

The invention discloses a synthesis process of an apremilast intermediate. The synthesis process comprises the following steps: (a) carrying out reaction on 3-ethoxyl-4-methoxystyrene and methanesulfonyl chloride under the action of a ruthenium catalyst to generate 4-[(1-chloro-2-methylsulfonyl)-ethyl]-2-ethoxyl-1-methoxybenzene; and (b) carrying out reaction on 4-[(1-chloro-2-methylsulfonyl)-ethyl]-2-ethoxyl-1-methoxybenzene and an alcohol liquid of ammonia, so as to obtain 1-(3-ethoxyl-4-methoxyl)phenyl-2-methylsulfonylethylamine. The synthesis process is simple and convenient to operate, and special reaction conditions are not needed, so that the synthesis process is more suitable for industrial production.