Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate

Base Information

Chemical Name:Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate
CAS No.:885100-76-5
Molecular Formula:C16H19FN2O2S
Molecular Weight:322.403
Hs Code.:
Mol file:885100-76-5.mol

Synonyms:Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate;6-(4-Fluorophenyl)-1,4-dihydro-4-(1-Methylethyl)-2-(Methylthio)-5-pyriMidinecarboxylic acid Methyl Ester

Suppliers and Price of Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 8 raw suppliers

Chemical Property of Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate

Chemical Property:

PSA：75.99000
LogP:2.82100

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate

There total 3 articles about Methyl 6-(4-Fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine -5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 122549-26-2
methyl 2-(4-fluorophenyl)methylidene-3-oxo-4-methylpentanoate

: 867-44-7,147895-43-0
S-Methylisothiourea sulfate

: 885100-76-5
methyl 6-(4-fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 25 - 75 ℃; for 17h;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 885100-76-5
methyl 6-(4-fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; piperidine / isopropyl alcohol / 0.5 h / 30 °C

2: sodium hydrogencarbonate / isopropyl alcohol / 0.17 h / 100 °C

With piperidine; sodium hydrogencarbonate; acetic acid; In isopropyl alcohol;

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 885100-76-5
methyl 6-(4-fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; piperidine / isopropyl alcohol / 0.5 h / 30 °C

2: sodium hydrogencarbonate / isopropyl alcohol / 0.17 h / 100 °C

With piperidine; sodium hydrogencarbonate; acetic acid; In isopropyl alcohol;