5,7-dibromo-8-benzyloxyquinoline

Base Information

• Chemical Name: 5,7-dibromo-8-benzyloxyquinoline
• CAS No.: 84165-50-4
• Molecular Formula: C16H11Br2NO
• Molecular Weight: 393.077
• Mol file: 84165-50-4.mol

Synonyms:5,7-dibromo-8-benzyloxyquinoline;8-benzyloxy-5,7-dibromoquinoline

Chemical Property of 5,7-dibromo-8-benzyloxyquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 5.33880

Purity/Quality:

97% ^*data from raw suppliers

8-(Benzyloxy)-5,7-dibromoquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-dibromo-8-benzyloxyquinoline

There total 3 articles about 5,7-dibromo-8-benzyloxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

broxyquinoline (521-74-4) + benzyl chloride (100-44-7) → 8-benzyloxy-5,7-dibromoquinoline (84165-50-4)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; water; at 25 ℃; for 4h;

DOI:10.1055/s-1982-29976

Reference yield: 43.4%

broxyquinoline (521-74-4) + benzyl bromide (100-39-0) → 8-benzyloxy-5,7-dibromoquinoline (84165-50-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 100 ℃; for 20h;

DOI:10.1039/b600912c

Reference yield:

8-quinolinol (148-24-3,24804-14-6) → 8-benzyloxy-5,7-dibromoquinoline (84165-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / 0.33 h / 20 °C

2: potassium carbonate; potassium iodide / acetone / 10 h / Inert atmosphere; Reflux

With bromine; potassium carbonate; acetic acid; potassium iodide; In acetone;

DOI:10.1016/j.dyepig.2013.12.007

upstream raw materials:

broxyquinoline

benzyl chloride

benzyl bromide

8-quinolinol

Downstream raw materials:

8-benzyloxy-5,7-bis(biphenyl-4-yl)quinoline

8-benzyloxy-5,7-diphenylquinoline

8-hydroxy-5,7-diphenylquinoline

5,7-bis(p-methoxyphenyl)-8-benzyloxyquinoline