[2-oxo-5-(trifluoromethyl)-1(2H)-pyridinyl]acetic acid(SALTDATA: FREE)

Base Information

• Chemical Name: [2-oxo-5-(trifluoromethyl)-1(2H)-pyridinyl]acetic acid(SALTDATA: FREE)
• CAS No.: 308294-33-9
• Molecular Formula: C8H6F3NO3
• Molecular Weight: 221.136
• Mol file: 308294-33-9.mol

Synonyms:[2-oxo-5-(trifluoromethyl)-1(2H)-pyridinyl]acetic acid(SALTDATA: FREE)

Chemical Property of [2-oxo-5-(trifluoromethyl)-1(2H)-pyridinyl]acetic acid(SALTDATA: FREE)

Chemical Property:

• Boiling Point: 347.9±42.0 °C(Predicted)
• PKA: 3.67±0.10(Predicted)
• PSA: 59.30000
• Density: 1.537±0.06 g/cm3(Predicted)
• LogP: 0.95170

Purity/Quality:

97% ^*data from raw suppliers

2-(2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-oxo-5-(trifluoromethyl)-1(2H)-pyridinyl]acetic acid(SALTDATA: FREE)

There total 3 articles about [2-oxo-5-(trifluoromethyl)-1(2H)-pyridinyl]acetic acid(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-oxo-5-trifluoromethyl-2H-pyridin-1-yl)-acetic acid tert-butyl ester → 2-(2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)acetic acid (308294-33-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1016/S0960-894X(02)00160-9

Reference yield:

5-(trifluoromethyl)-2(1H)-pyridone (33252-63-0,79894-13-6) → 2-(2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)acetic acid (308294-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 4 N HCl / dioxane; diethyl ether

With hydrogenchloride; sodium hydride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00160-9

Reference yield:

→ 2-(2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)acetic acid (308294-33-9)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃; for 2h;

upstream raw materials:

5-(trifluoromethyl)-2(1H)-pyridone