(2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL

Base Information

• Chemical Name: (2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL
• CAS No.: 114673-68-6
• Molecular Weight: 197.23
• Mol file: 114673-68-6.mol

Synonyms:(2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL;(R)-2-Amino-2-(3,4-dimethoxyphenyl)ethanol

Chemical Property of (2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL

There total 9 articles about (2R)-2-AMINO-2-(3,4-DIMETHOXYPHENYL)ETHAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2S)-(+)-3,4-dimethoxyphenylglycine (147383-98-0) → (2S)-(+)-2-amino-2-(3,4-dimethoxyphenyl)ethanol (114673-69-7,114673-68-6)

Guidance literature:

With lithium borohydride; chloro-trimethyl-silane; In tetrahydrofuran; at 0 - 20 ℃; for 25h;

DOI:10.1002/1099-0690(200111)2001:22<4343::AID-EJOC4343>3.0.CO;2-D

Reference yield: 47.6%

→ 2-amino-2-(3,4-dimethoxyphenyl)ethanol (114606-60-9,114673-68-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Reflux;

Reference yield:

C12H12Cl3NO3 → 2-amino-2-(3,4-dimethoxyphenyl)ethanol (114606-60-9,114673-68-6)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h;

DOI:10.1002/anie.202008806

upstream raw materials:

2-(3,4-dimethoxyphenyl)ethyl 2,2,2-trichloroethanimidate

(2S)-(+)-3,4-dimethoxyphenylglycine

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2-(3,4-dimethoxyphenyl)-N-methylacetamide

[2S,1'S,2'S]-(+)-2-amino-2-(3,4-dimethoxyphenyl)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylacetamide