(2S)-(+)-3,4-dimethoxyphenylglycine

Base Information

• Chemical Name: (2S)-(+)-3,4-dimethoxyphenylglycine
• CAS No.: 147383-98-0
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.218
• Mol file: 147383-98-0.mol

Synonyms:(2S)-(+)-3,4-dimethoxyphenylglycine

Chemical Property of (2S)-(+)-3,4-dimethoxyphenylglycine

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-alpha-Amino-3,4-dimethoxybenzeneacetic acid 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-(+)-3,4-dimethoxyphenylglycine

There total 6 articles about (2S)-(+)-3,4-dimethoxyphenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

[2S,1'S,2'S]-(+)-2-amino-2-(3,4-dimethoxyphenyl)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylacetamide (250665-97-5) → (2S)-(+)-3,4-dimethoxyphenylglycine (147383-98-0)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; Heating;

DOI:10.1016/S0040-4039(99)01475-6

Reference yield:

C15H19NO7 (1141847-01-9) → 1,5-pentanedioic acid (110-94-1) + C10H13NO4 (117446-20-5) + C15H19NO7 (1141847-07-5) + (2S)-(+)-3,4-dimethoxyphenylglycine (147383-98-0)

Guidance literature:

With glutaryl acylase; water; sodium carbonate; In methanol; at 37 ℃; pH=8.0; optical yield given as %ee; Resolution of racemate; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/adsc.200800203

Reference yield:

C15H19NO7 (1141847-01-9) → 1,5-pentanedioic acid (110-94-1) + C15H19NO7 (1141847-07-5) + (2S)-(+)-3,4-dimethoxyphenylglycine (147383-98-0)

Guidance literature:

With glutaryl acylase; water; sodium carbonate; at 37 ℃; pH=8.0; optical yield given as %ee; enantioselective reaction; Resolution of racemate; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/adsc.200800203

upstream raw materials:

[2S,1'S,2'S]-(+)-2-amino-2-(3,4-dimethoxyphenyl)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylacetamide

(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2-(3,4-dimethoxyphenyl)-N-methylacetamide

[2S,1'S,2'S]-(+)-2-(3,4-dimethoxyphenyl)-2-[N,N'-bis(1,1-dimethylethoxycarbonyl)hydrazino]-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methylacetamide

C₁₅H₁₉NO₇

Downstream raw materials:

methyl (2S)-(+)-2-amino-2-(3,4-dimethoxyphenyl)acetate

(2S)-(+)-2-amino-2-(3,4-dimethoxyphenyl)ethanol

(2S)-(-)-2-[(E)-2,3-dimethoxybenzylideneamino]-2-(3,4-dimethoxyphenyl)ethanol

(2S)-(+)-2-(2,3-dimethoxybenzyl)amino-2-(3,4-dimethoxyphenyl)ethanol