1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl

Base Information

• Chemical Name: 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl
• CAS No.: 1799612-11-5
• Molecular Formula: C20H32BClN2O3
• Molecular Weight: 394.74
• Mol file: 1799612-11-5.mol

Synonyms:1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl

Chemical Property of 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl

Chemical Property:

• Boiling Point: 500.1±50.0 °C(Predicted)
• PKA: 7.57±0.10(Predicted)
• PSA: 34.17000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 2.44960
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)-4-methylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl

There total 14 articles about 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + 1-[2-(4-bromo-2-chloro-3-methylphenoxy)ethyl]-4-methylpiperazine → 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)phenoxy)ethyl)-4-methylpiperazine (1799612-11-5)

Guidance literature:

1-[2-(4-bromo-2-chloro-3-methylphenoxy)ethyl]-4-methylpiperazine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; at -78 ℃;

Reference yield: 81.0%

2-(4-methylpiperazinyl)ethanol (5464-12-0) + 2-chloro-3-methyl-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)phenoxy)ethyl)-4-methylpiperazine (1799612-11-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In toluene; at 50 ℃; Inert atmosphere;

Reference yield: 48.0%

1-[2-(4-bromo-2-chloro-3-methylphenoxy)ethyl]-4-methylpiperazine dihydrochloride + bis(pinacol)diborane (73183-34-3) → 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)phenoxy)ethyl)-4-methylpiperazine (1799612-11-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; for 16h; Inert atmosphere; Reflux;

upstream raw materials:

4-bromo-2-chloro-3-methylphenol

2-(4-methylpiperazinyl)ethanol

4-bromo-2-chlorophenol

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane