Curcumin-d6

Base Information

Chemical Name:Curcumin-d6
CAS No.:1246833-26-0
Molecular Formula:C₂₁H₂₀O₆
Molecular Weight:374.339
Hs Code.:
DSSTox Substance ID:DTXSID80703461
Wikidata:Q82635629
Mol file:1246833-26-0.mol

Synonyms:Curcumin-d6;1246833-26-0;(1E,6E)-1,7-bis[4-hydroxy-3-(trideuteriomethoxy)phenyl]hepta-1,6-diene-3,5-dione;Curcumin D6;HY-N0005S;DTXSID80703461;AKOS016339629;AKOS040732883;SS-4521;CS-0111679;(1E,6E)-1,7-Bis{4-hydroxy-3-[(~2~H_3_)methyloxy]phenyl}hepta-1,6-diene-3,5-dione

Suppliers and Price of Curcumin-d6

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Curcumin-d6
5mg
$ 446.00

TRC
Curcumin-d6
5mg
$ 175.00

American Custom Chemicals Corporation
CURCUMIN-D6 95.00%
50MG
$ 2760.00

American Custom Chemicals Corporation
CURCUMIN-D6 95.00%
10MG
$ 1871.10

American Custom Chemicals Corporation
CURCUMIN-D6 95.00%
5MG
$ 774.40

American Custom Chemicals Corporation
CURCUMIN-D6 95.00%
1MG
$ 567.00

Total 6 raw suppliers

Chemical Property of Curcumin-d6

Chemical Property:

Melting Point:184-186°C
PSA：93.06000
LogP:3.36990
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly, Sonicated), DMSO (Slightly)
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:374.16364883
Heavy Atom Count:27
Complexity:507

Purity/Quality:

99% ^*data from raw suppliers

Curcumin-d6 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
Isomeric SMILES:[2H]C(OC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC([2H])([2H])[2H])O)([2H])[2H]
Uses Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Technology Process of Curcumin-d6

There total 2 articles about Curcumin-d6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 123-54-6,81235-32-7
acetylacetone

: 74495-74-2
4-hydroxy-3-[²H₃]methoxybenzaldehyde

: 1246833-26-0
[d6]curcumin

Guidance literature:: acetylacetone; With boron trioxide; for 16h;

(2H₃)-4-hydroxy-3-methoxybenzaldehyde; With boric acid tributyl ester; In ethyl acetate; for 0.0833333h;

With N-butylamine; In ethyl acetate; for 17h;
DOI:10.1002/jlcr.3102

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1246833-26-0
[d6]curcumin

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; N,N-dimethyl acetamide; toluene / 2 h

2.1: boron trioxide / 16 h

2.2: 0.08 h

2.3: 17 h

With boron trioxide; sodium hydroxide; In methanol; N,N-dimethyl acetamide; toluene;
DOI:10.1002/jlcr.3102