GSK2194069

Base Information

Chemical Name:GSK2194069
CAS No.:1332331-08-4
Molecular Formula:C25H24N4O3
Molecular Weight:428.491
Hs Code.:
Mol file:1332331-08-4.mol

Synonyms:GSK2194069;4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Suppliers and Price of GSK2194069

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GSK2194069
25mg
$ 550.00

TRC
GSK2194069
1mg
$ 45.00

Tocris
GSK2194069 ≥99%(HPLC)
5
$ 147.00

Tocris
GSK2194069 ≥99%(HPLC)
25
$ 558.00

Crysdot
GSK2194069 98+%
10mg
$ 350.00

Crysdot
GSK2194069 98+%
50mg
$ 1050.00

Crysdot
GSK2194069 98+%
100mg
$ 1470.00

Crysdot
GSK2194069 98+%
5mg
$ 245.00

Cayman Chemical
GSK2194069 ≥98%
1mg
$ 38.00

Cayman Chemical
GSK2194069 ≥98%
500μg
$ 25.00

Total 9 raw suppliers

Chemical Property of GSK2194069

Chemical Property:

PKA:6.15±0.20(Predicted)
PSA：84.13000
Density:1.44±0.1 g/cm3(Predicted)
LogP:3.71270
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

GSK2194069 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.

Technology Process of GSK2194069

There total 11 articles about GSK2194069 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₂₅H₂₆N₄O₄

: 1332331-08-4
GSK 2194069

Guidance literature:: With potassium carbonate; In water; isopropyl alcohol; Reflux;

Reference yield:

: 204688-61-9
2‐[(3S)‐1‐[(tert‐butoxy)carbonyl]pyrrolidin‐3‐yl]acetic acid

: 1332331-08-4
GSK 2194069

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / diethyl ether / 40 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.2: 0.08 h / 20 °C

2.3: 1 h / 0 - 20 °C

3.1: hydrazine hydrate / ethanol / 15 h / 80 °C

4.1: dichloromethane / 27 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / water / 18 h / 70 - 130 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 100 °C

With hydrogenchloride; potassium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: 2493-02-9
4-bromophenyl isocyanate

: 1332331-08-4
GSK 2194069

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 27 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / water / 18 h / 70 - 130 °C

3: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 100 °C

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water;