1-(1-Benzhydrylazetidin-3-yl)pyrrolidine

Base Information

• Chemical Name: 1-(1-Benzhydrylazetidin-3-yl)pyrrolidine
• CAS No.: 55438-67-0
• Molecular Formula: C₂₀H₂₄N₂
• Molecular Weight: 292.424
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80437638
• Wikidata: Q82253176
• Mol file: 55438-67-0.mol

Synonyms:1-(1-benzhydrylazetidin-3-yl)pyrrolidine;55438-67-0;1-[1-(Diphenylmethyl)-3-azetidinyl]pyrrolidine;1-(1-(DIPHENYLMETHYL)-3-AZETIDINYL)PYRROLIDINE;SCHEMBL3263017;DTXSID80437638;GVMPKWBOEMVYOE-UHFFFAOYSA-N;SB51768;1-(1-benzhydryl-azetidin-3-yl)-pyrrolidine;1-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL]PYRROLIDINE

Chemical Property of 1-(1-Benzhydrylazetidin-3-yl)pyrrolidine

Chemical Property:

• PSA: 6.48000
• LogP: 3.43180
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 292.193948774
• Heavy Atom Count: 22
• Complexity: 314

Purity/Quality:

99% ^*data from raw suppliers

1-(1-Benzhydrylazetidin-3-yl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)C2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 1-(1-Benzhydrylazetidin-3-yl)pyrrolidine

There total 2 articles about 1-(1-Benzhydrylazetidin-3-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

pyrrolidine (123-75-1) + 1-benzhydryl-3-azetidinyl methanesulfonate (33301-41-6) → 1-(1-benzhydrylazetidin-3-yl)pyrrolidine (55438-67-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) → 1-(1-benzhydrylazetidin-3-yl)pyrrolidine (55438-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C / Sealed tube

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1021/acs.joc.0c01831

upstream raw materials:

pyrrolidine

1-benzhydryl-3-azetidinyl methanesulfonate

1-(diphenylmethyl)-3-hydroxyazetidine