3-(Pyrrolidin-3-yloxy)pyridine

Base Information

• Chemical Name: 3-(Pyrrolidin-3-yloxy)pyridine
• CAS No.: 224818-27-3
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.207
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60436225
• Nikkaji Number: J1.320.990A
• ChEMBL ID: CHEMBL273218
• Mol file: 224818-27-3.mol

Synonyms:3-(pyrrolidin-3-yloxy)pyridine;224818-27-3;3-(Pyrrolidin-3-yloxy)-pyridine;3-pyrrolidin-3-yloxypyridine;3-(3-pyrrolidinyloxy)pyridine;CHEMBL273218;F2147-1456;SCHEMBL6306148;3-(3-Pyrrolidinyloxy)-pyridine;DTXSID60436225;DCWKRPJLVIHGCZ-UHFFFAOYSA-N;ZIA81827;BDBM50088442;AKOS005263763;SB35588;PD120923;3-(3-Pyrrolidinyloxy)pyridine, AldrichCPR;CS-0449782;FT-0769833;EN300-108586;Z1095384991

Chemical Property of 3-(Pyrrolidin-3-yloxy)pyridine

Chemical Property:

• PSA: 34.15000
• LogP: 1.15110
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

98% ^*data from raw suppliers

3-(Pyrrolidin-3-yloxy)-pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC1OC2=CN=CC=C2

Technology Process of 3-(Pyrrolidin-3-yloxy)pyridine

There total 8 articles about 3-(Pyrrolidin-3-yloxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(+/-)-3-oxy(3-pyridyl)-1-tert-butoxycarbonylpyrrolidine (224818-73-9) → 3-(3-Pyrrolidinyloxy)-pyridine (224818-27-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 6h;

DOI:10.1021/jm990973d

Reference yield:

tert-butyl (S)-3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate → (S)-3-(pyrrolidin-3-yloxy)pyridine (224818-27-3)

Guidance literature:

With LiAlH₄; trifluoroacetic acid; sodium chloride; In dichloromethane;

Reference yield:

(R)-3-(pyridin-3-yloxy)pyrrolidine-1-carboxylic acid tert-butyl ester → (R)-3-(pyrrolidin-3-yloxy)pyridine (259261-88-6,224818-27-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm060653b

upstream raw materials:

3-HYDROXYPYRIDINE

(+/-)-3-oxy(3-pyridyl)-1-tert-butoxycarbonylpyrrolidine

Refernces

• 1、 -. "POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4". Paragraph 0727; 0729. . Retrieved 2018/02/03.
• 2、 -. "PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION". Page 11. . Retrieved 2010/02/07.