2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

Base Information

Chemical Name:2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
CAS No.:910904-64-2
Molecular Formula:C16H19N5O3
Molecular Weight:329.359
Hs Code.:2933990090
Mol file:910904-64-2.mol

Synonyms:2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

Suppliers and Price of 2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-Nitro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidin-2-amine 95+%
1g
$ 535.00

Chemenu
5-nitro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidin-2-amine 95%
1g
$ 505.00

American Custom Chemicals Corporation
5-NITRO-N-(4-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)PYRIMIDIN-2-AMINE 95.00%
5MG
$ 497.53

Total 4 raw suppliers

Chemical Property of 2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

Chemical Property:

Boiling Point:545.9±60.0 °C(Predicted)
PKA:9?+-.0.20(Predicted)
PSA：96.10000
Density:1.317±0.06 g/cm3(Predicted)
LogP:3.13710
Storage Temp.:2-8°C

Purity/Quality:

97%+ ^*data from raw suppliers

5-Nitro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

There total 1 articles about 2-PyriMidinaMine, 5-nitro-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 3073-77-6
5-nitropyrimidin-2-amine

: 1081-73-8
1-[2-(4-bromophenoxy)ethyl]pyrrolidine

: 910904-64-2
(5-nitro-pyrimidin-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 2 - 18h; Product distribution / selectivity; Heating / reflux;

Reference yield: 26.0%

: 910904-64-2
(5-nitro-pyrimidin-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

: 910904-67-5
N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyrimidine-2,5-diamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1 - 2h; Product distribution / selectivity;

Reference yield:

: 910904-64-2
(5-nitro-pyrimidin-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

: 2-chloro-N-(2-((4-(2-(1-oxidopyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-5-yl)-5-(((3-(trifluoromethyl)phenyl)carbonyl)amino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;