(4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

Base Information

• Chemical Name: (4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone
• CAS No.: 1393345-76-0
• Molecular Formula: C₂₄H₂₃NO₂
• Molecular Weight: 357.452
• Mol file: 1393345-76-0.mol

Synonyms:(4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone;JWH 081 4-hydroxynaphthyl metabolite

Chemical Property of (4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

JWH 081 4-hydroxynaphthyl metabolite ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone is an metabolite of JWH 081 (P283600), an analgesic chemical which acts as a cannabinoid agonist at the CB1 and CB2 receptors.

Technology Process of (4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

There total 6 articles about (4-Hydroxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

[1-(5-fluoropentyl)-1H-indole-3-yl](naphthalene-1-yl)methanone (335161-24-5) + JWH-081 (210179-46-7) → 4-hydroxynaphthalen-1-yl-(1-pentylindol-3-yl) methanone (1393345-76-0)

Guidance literature:

In n-heptane; dichloromethane; ethyl acetate;

Reference yield:

naphthalene-1-carbonic acid chloride (879-18-5) → 4-hydroxynaphthalen-1-yl-(1-pentylindol-3-yl) methanone (1393345-76-0)

Guidance literature:

Multi-step reaction with 5 steps

1: methylmagnesium bromide; ammonium chloride

2: ammonium chloride; thiophen-2-yl magnesium bromide / diethyl ether; thionyl chloride

3: ethyl acetate; mineral oil; hexane

4: water; ethyl acetate; mineral oil; hexane

5: ethyl acetate; dichloromethane; n-heptane

With methylmagnesium bromide; ammonium chloride; thiophen-2-yl magnesium bromide; In thionyl chloride; diethyl ether; hexane; n-heptane; dichloromethane; water; ethyl acetate; mineral oil;

Reference yield:

(1H-indol-3-yl)(naphthalene-1-yl)methanone (109555-87-5) → 4-hydroxynaphthalen-1-yl-(1-pentylindol-3-yl) methanone (1393345-76-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium chloride; thiophen-2-yl magnesium bromide / diethyl ether; thionyl chloride

2: ethyl acetate; mineral oil; hexane

3: water; ethyl acetate; mineral oil; hexane

4: ethyl acetate; dichloromethane; n-heptane

With ammonium chloride; thiophen-2-yl magnesium bromide; In thionyl chloride; diethyl ether; hexane; n-heptane; dichloromethane; water; ethyl acetate; mineral oil;

upstream raw materials:

(2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone

naphthalene-1-carbonic acid chloride

(1H-indol-3-yl)(naphthalene-1-yl)methanone

[1-(5-fluoropentyl)-1H-indole-3-yl](naphthalene-1-yl)methanone

Downstream raw materials:

(5-hydroxy-1-pentyl-1H-indol-3-yl)(naphthalen-1-yl)methanone

Refernces