(2-Methyl-1H-indol-3-yl)-1-naphthalenylmethanone

Base Information

• Chemical Name: (2-Methyl-1H-indol-3-yl)-1-naphthalenylmethanone
• CAS No.: 80749-33-3
• Molecular Formula: C20H15NO
• Molecular Weight: 285.345
• Hs Code.: 2933990090
• Mol file: 80749-33-3.mol

Synonyms:(2-Methyl-1H-indol-3-yl)-1-naphthalenylmethanone;(2-Methyl-1H-indol-3-yl)(naphthalen-1-yl)methanone;(2-methyl-indol-3-yl)-[1]naphthyl ketone;(2-methyl-1H-indol-3-yl)(1-naphthenyl)methanone;2-methyl-3-(1-naphthylcarbonyl)indole;(2-Methyl-indol-3-yl)-[1]naphthyl-keton;2-methyl-3-(1-naphthoyl)indole;

Chemical Property of (2-Methyl-1H-indol-3-yl)-1-naphthalenylmethanone

Chemical Property:

• Melting Point: 229-230℃
• PSA: 32.86000
• Density: 1.238
• LogP: 4.86050

Purity/Quality:

99% ^*data from raw suppliers

(2-Methyl-1H-indol-3-yl)(naphthalen-1-yl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Methyl-1H-indol-3-yl)-1-naphthalenylmethanone

There total 7 articles about (2-Methyl-1H-indol-3-yl)-1-naphthalenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-methyl-1H-indole (95-20-5) + naphthalene-1-carbonic acid chloride (879-18-5) → (2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone (80749-33-3)

Guidance literature:

2-methyl-1H-indole; With methylmagnesium bromide; In diethyl ether; at 0 - 20 ℃;

naphthalene-1-carbonic acid chloride; In diethyl ether; at 20 ℃; for 1.5h; Reflux;

In diethyl ether;

Reference yield: 45.0%

2-methyl-1H-indole (95-20-5) + 1-naphthalenecarboxylic acid (86-55-5) + 2-methoxyphenylacetic acid (93-25-4) → (2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone (80749-33-3)

Guidance literature:

With ammonium chloride; thiophen-2-yl magnesium bromide; In thionyl chloride; diethyl ether;

Reference yield: 45.0%

2-methyl-1H-indole (95-20-5) + 1-naphthalenecarboxylic acid (86-55-5) + (1H-indol-3-yl)(naphthalene-1-yl)methanone (109555-87-5) → (2-methyl-1H-indol-3-yl)(naphthalen-1-yl) methanone (80749-33-3)

Guidance literature:

With ammonium chloride; thiophen-2-yl magnesium bromide; In thionyl chloride; diethyl ether;

upstream raw materials:

2-methyl-1H-indole

ethylmagnesium bromide

naphthalene-1-carbonic acid chloride

1-naphthalenecarboxylic acid

Downstream raw materials:

2-Methoxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester

2-Hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester

2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

1-(1H-indol-3-yl)-2-(2-methoxyphenyl)ethanone

Refernces

• 1、 -. "Detection of synthetic cannabinoids". Page/Page column. . Retrieved 2014/03/22.
• 2、 -. "Multitarget Compounds Active at a PPAR and Cannabinoid Receptor". Page/Page column 47. . Retrieved 2011/04/13.