2-Chloro-5-(difluoromethyl)pyridine

Base Information

• Chemical Name: 2-Chloro-5-(difluoromethyl)pyridine
• CAS No.: 71701-99-0
• Molecular Formula: C6H4ClF2N
• Molecular Weight: 163.5524664
• Hs Code.: 2933399990
• Mol file: 71701-99-0.mol

Synonyms:2-Chloro-5-(difluoromethyl)pyridine;2-Chloro-5-(difluoromethyl)pyridine 97%;6-Chloro-alpha,alpha-difluoro-3-picoline

Chemical Property of 2-Chloro-5-(difluoromethyl)pyridine

Chemical Property:

• Refractive Index: n20/D 1.492
• Boiling Point: 215.1±35.0 °C(Predicted)
• PKA: -1.82±0.10(Predicted)
• Flash Point: 107°C
• PSA: 12.89000
• Density: 1.368g/mLat 25℃
• LogP: 2.67260
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-5-(difluoromethyl)-Pyridine 97.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-(difluoromethyl)pyridine

There total 3 articles about 2-Chloro-5-(difluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

ethyl 2-(6-chloropyridin-3-yl)-2,2-difluoroacetate → 2-chloro-5-(trifluoromethyl)pyridine (71701-99-0)

Guidance literature:

With potassium fluoride; In 1-methyl-pyrrolidin-2-one; water; at 200 ℃; for 4h; Schlenk technique; Inert atmosphere;

Reference yield:

6-chloronicotinylaldehyde (23100-12-1) → 2-chloro-5-(trifluoromethyl)pyridine (71701-99-0)

Guidance literature:

With dimethylaminosulphur trifluoride; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jm070131b

Reference yield:

→ 2-chloro-5-(trifluoromethyl)pyridine (71701-99-0)

Guidance literature:

upstream raw materials:

6-chloronicotinylaldehyde

Downstream raw materials:

2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

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