2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

Base Information

Chemical Name:2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide
CAS No.:947371-16-6
Molecular Formula:C₂₇H₂₅BrClF₂N₃O₂
Molecular Weight:576.868
Hs Code.:

Synonyms:2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

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Chemical Property of 2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

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Technology Process of 2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

There total 7 articles about 2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 610791-48-5,701977-22-2
N-(1S,2S)-[2-(3-cyanophenyl)-3-(4-chlorophenyl)-1-methylpropyl]amine hydrochloride

: C₁₀H₉BrClF₂NO₂

: 947371-16-6
2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

Guidance literature:: With 4-methyl-morpholine; In acetonitrile; at 5 - 10 ℃; for 0.5h;
DOI:10.1021/jm070131b

Reference yield:

: 71701-99-0
2-chloro-5-(trifluoromethyl)pyridine

: 947371-16-6
2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(trimethylsilyl)amide / tetrahydrofuran / 0.17 h / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: imidazole / dimethylformamide / 20 °C

3.1: N-bromosuccinimide / CCl₄ / 48 h / Irradiation

3.2: aq. hydrochloric acid / tetrahydrofuran; CCl₄ / 0.5 h / 20 °C

4.1: thionyl chloride / toluene / 1 h

5.1: N-methylmorpholine / acetonitrile / 0.5 h / 5 - 10 °C

With 4-methyl-morpholine; 1H-imidazole; N-Bromosuccinimide; thionyl chloride; hexamethyldisilazide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm070131b

Reference yield:

: 947371-39-3
2-(5-bromodifluoromethyl-2-pyridyloxy)-2-methylpropionic acid

: 947371-16-6
2-({5-[bromo(difluoro)methyl]pyridin-2-yl}oxy)-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 1 h

2: N-methylmorpholine / acetonitrile / 0.5 h / 5 - 10 °C

With 4-methyl-morpholine; thionyl chloride; In toluene; acetonitrile;
DOI:10.1021/jm070131b