3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine

Base Information

Chemical Name:3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine
CAS No.:87736-83-2
Molecular Formula:C15H23F3N2OSi
Molecular Weight:332.441
Hs Code.:
DSSTox Substance ID:DTXSID70516860
Wikidata:Q82378494
Mol file:87736-83-2.mol

Synonyms:87736-83-2;4-[3-(Trifluoromethyl)-3H-diaziridine]benzyl Alcohol tert-Butyl(dimethyl)silyl Ether;tert-butyl-dimethyl-[[4-[3-(trifluoromethyl)diaziridin-3-yl]phenyl]methoxy]silane;3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine;3-[4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]-3-(trifluoromethyl)-diaziridine;SCHEMBL993759;DTXSID70516860;MFCD31563430;WS-01619;FT-0675535;D85574;3-(4-((tert.-butyldimethylsilyloxy)methyl)phenyl)-3-(trifluoromethyl)-diaziridine;3-(4-((tert.-Butyldimethylsilyloxy)methyl)phenyl)-3-(trifluoromethyl)diaziridine;4-[3-(Trifluoromethyl)-3H-diaZiridine]benZyl alcohol t-butyl(dimethyl)silyl ether

Suppliers and Price of 3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[3-(Trifluoromethyl)-3H-diaziridine]benzylAlcoholtert-Butyl(dimethyl)silylEther
250mg
$ 1585.00

Medical Isotopes, Inc.
4-[3-(Trifluoromethyl)-3H-diaziridine]benzylAlcoholtert-Butyl(dimethyl)silylEther
25 mg
$ 680.00

Total 3 raw suppliers

Chemical Property of 3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine

Chemical Property:

PSA：53.11000
LogP:4.68890
Storage Temp.:Refrigerator
Solubility.:Dichloromethane, Ethyl Acetate, Methanol
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:332.15317438
Heavy Atom Count:22
Complexity:395

Purity/Quality:: 4-[3-(Trifluoromethyl)-3H-diaziridine]benzylAlcoholtert-Butyl(dimethyl)silylEther ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC1=CC=C(C=C1)C2(NN2)C(F)(F)F
Uses Photo-induced crosslinking reagent.

Technology Process of 3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine

There total 13 articles about 3-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-3-(trifluoromethyl)diaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 87736-80-9
4-[(tert-butyldimethylsiloxy)methyl]-2,2,2-trifluoroacetophenone-O-(4-toluenesulfonyl) oxime

: 87736-83-2
3-<4-<(tert-butyldimethylsiloxy)methyl>phenyl>-3-trifluoromethyldiaziridine

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at -78 - 20 ℃; for 48h; Sealed tube;
DOI:10.1021/jo402738t

Reference yield: 86.0%

: 87736-80-9
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone O-(p-tolylsulfonyl)oxime

: 87736-83-2
3-<4-<(tert-butyldimethylsiloxy)methyl>phenyl>-3-trifluoromethyldiaziridine

Guidance literature:: With ammonia; In diethyl ether; for 12h; Ambient temperature;

Reference yield:

: 87736-75-2
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone

: 87736-83-2
3-<4-<(tert-butyldimethylsiloxy)methyl>phenyl>-3-trifluoromethyldiaziridine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NH₃OHCl, NaOH / ethanol / 16 h / Heating

2: 70 percent / pyridine / 3 h / Heating

3: 86 percent / liq. NH₃ / diethyl ether / 12 h / Ambient temperature

With sodium hydroxide; hydroxylamine hydrochloride; ammonia; In pyridine; diethyl ether; ethanol;