1-Methyl-3-thiophen-2-ylpiperazine

Base Information

Chemical Name:1-Methyl-3-thiophen-2-ylpiperazine
CAS No.:85803-52-7
Molecular Formula:C₉H₁₄N₂S
Molecular Weight:182.29
Hs Code.:2934999090
DSSTox Substance ID:DTXSID70516385
Mol file:85803-52-7.mol

Synonyms:85803-52-7;1-METHYL-3-THIOPHEN-2-YLPIPERAZINE;1-methyl-3-(2-thienyl)piperazine;1-Methyl-3-(2-thienyl)-piperazine;1-methyl-3-(thiophen-2-yl)piperazine;PIPERAZINE, 1-METHYL-3-(2-THIENYL)- (9CI);SCHEMBL7012302;DTXSID70516385;LQUMPDKIHCGDTG-UHFFFAOYSA-N;AKOS015958114;AB91885;CS-0301046;EN300-235148;F79545;F2147-0818

Suppliers and Price of 1-Methyl-3-thiophen-2-ylpiperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
1-Methyl-3-(2-thienyl)-piperazine 97%
0.25g
$ 192.50

Acrotein
1-Methyl-3-(2-thienyl)-piperazine 97%
1g
$ 440.00

ACHEMBLOCK
1-Methyl-3-(2-thienyl)-piperazine 95%
250MG
$ 265.00

Total 6 raw suppliers

Chemical Property of 1-Methyl-3-thiophen-2-ylpiperazine

Chemical Property:

Boiling Point:287.4±30.0 °C(Predicted)
PKA:8.08±0.40(Predicted)
PSA：43.51000
Density:1.090±0.06 g/cm3(Predicted)
LogP:1.59090
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:182.08776963
Heavy Atom Count:12
Complexity:152

Purity/Quality:

95% ^*data from raw suppliers

1-Methyl-3-(2-thienyl)-piperazine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCNC(C1)C2=CC=CS2
Uses 1-Methyl-3-(2-thienyl)piperazine is used as a reactant in the preparation of thiophene ring analogs of mianserin.

Technology Process of 1-Methyl-3-thiophen-2-ylpiperazine

There total 4 articles about 1-Methyl-3-thiophen-2-ylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 85803-50-5
ethyl 3-(2-thienyl)piperazine-1-carboxylate

: 85803-52-7
1-methyl-3-(2-thienyl)piperazine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 12h; Heating;
DOI:10.1021/jm00362a006

Reference yield:

: 51445-63-7
oxo-thiophen-2-yl-acetaldehyde

: 85803-52-7
1-methyl-3-(2-thienyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 1.5 h

2: NaBH₄ / ethanol / 18 h

3: 30.0 g / acetic acid / a) 65 deg C, 1 h, b) RT, 16 h

4: 89 percent / LiAlH₄ / diethyl ether / 12 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; In diethyl ether; ethanol; acetic acid;
DOI:10.1021/jm00362a006

Reference yield:

: 5-Thiophen-2-yl-2,3-dihydro-pyrazine

: 85803-52-7
1-methyl-3-(2-thienyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / 18 h

2: 30.0 g / acetic acid / a) 65 deg C, 1 h, b) RT, 16 h

3: 89 percent / LiAlH₄ / diethyl ether / 12 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; In diethyl ether; ethanol; acetic acid;
DOI:10.1021/jm00362a006